2407-68-3Relevant articles and documents
Reichardt,Kermer
, p. 538 (1970)
Preparation method of 2-chloro-5-cyanopyrimidine compound
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Paragraph 0028; 0032, (2020/03/09)
The invention discloses a preparation method of a 2-chloro-5-cyanopyrimidine compound. A route adopted by the preparation method is as follows: cyanoacetic acid is used as a raw material, ioxane is used as a solvent, and a reaction is conducted under the action of N,N-dimethylformamide dimethyl acetal so as to generate 3-(dimethylamino)acrylonitrile, and then a Vilsmeier reaction, an addition reaction, a ring closing reaction and a chlorination reaction are sequentially carried out to finally obtain a finished product, i.e., the 2-chloro-5-cyanopyrimidine compound. According to the synthetic route provided by the preparation method, raw materials are cheap and easily available; aftertreatment is simple; purification is easy; column chromatographic purification is not needed in each step ofreaction; the method can effectively overcome the technical defects of long route, expensive raw material cost, need of column chromatography and the like of other synthesis methods in the prior art;and the preparation method of the 2-chloro-5-cyanopyrimidine compound provided by the invention has important economic benefits on reduction of the drug cost, and is a technology which is low in costand suitable for industrial production.
Hydrogenolysis of Amide Acetals and Iminium Esters
Kadyrov, Renat
, p. 170 - 172 (2017/12/26)
Amide acetals and iminium esters were hydrogenated into amines under very mild reaction conditions over common hydrogenation catalysts. This finding provides a new strategy for the selective reduction of amides. The synthetic utility of this approach was demonstrated by the selective reduction of amides bearing ester and nitrile groups.
