120503-69-7 Usage
Description
2-Amino-6-cyclopropylamino-9H-purine is an organic compound with the molecular formula C8H9N5. It is a derivative of purine, a central component of the nucleic acids adenine and guanine, and plays a significant role in various biological processes.
Uses
Used in Pharmaceutical Industry:
2-Amino-6-cyclopropylamino-9H-purine is used as an impurity in the production of Abacavir Sulfate (A105000), a nucleoside reverse transcriptase inhibitor. 2-Amino-6-cyclopropylamino-9H-purine is essential in the development and manufacturing of antiviral medications, particularly for the treatment of HIV-1 infection.
Used in Chemical Synthesis:
2-Amino-6-cyclopropylamino-9H-purine is used as a key intermediate in the preparation of purine derivatives, which are known as AMPK activating compounds. These compounds have potential applications in the development of drugs targeting metabolic diseases and conditions related to energy homeostasis.
Check Digit Verification of cas no
The CAS Registry Mumber 120503-69-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,0 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 120503-69:
(8*1)+(7*2)+(6*0)+(5*5)+(4*0)+(3*3)+(2*6)+(1*9)=77
77 % 10 = 7
So 120503-69-7 is a valid CAS Registry Number.
120503-69-7Relevant articles and documents
Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
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Paragraph 0049-0050, (2014/10/16)
The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.
An efficient, general asymmetric synthesis of carbocyclic nucleosides: Application of an asymmetric aldol/ring-closing metathesis strategy
Crimmins,King,Zuercher,Choy
, p. 8499 - 8509 (2007/10/03)
A general and efficient synthesis of carbocyclic and hexenopyranosyl nucleosides has been developed. The strategy combines three key transformations: an asymmetric aldol addition to establish the relative and absolute configuration of the pseudosugar, a ring-closing metathesis to construct the pseudosugar ring, and a Trost-type palladium(0)-mediated substitution to assemble the pseudosugar and the aromatic base. Carbovir, abacavir, and their 2'-methyl derivatives as well as hexenopyranosyl nucleoside analogues have been prepared by this sequence.
