124778-95-6Relevant articles and documents
FeCl3 and Yb(OTf)3 Mediated Conversion of Acetates of the Baylis-Hillman Adducts into (Z) and (E) Trisubstituted Alkenes
Krishna, Palakodety Radha,Kannan,Sharma
, p. 55 - 64 (2007/10/03)
Anhydrous FeCl3 and Yb(OTf)3 are utilised as new reagents for the stereoselective isomerisation of acetates of the Baylis-Hillman adducts to both (Z) and (E) trisubstituted alkenes respectively.
Potential Inhibitors of Phosphoenolpyruvate Carboxylase. II. Phosphonic Acid Substrate Analogues Derived from Reactions of Trialkyl Phosphites with Halomethacrylates
McFadden, Helen G.,Harris, Roger L. N.,Jenkins, Colin L. D.
, p. 301 - 314 (2007/10/02)
Analogues of phosphoenolpyruvate (PEP), the substrate of PEP carboxylase, were synthesized as potential inhibitors of the enzyme.Esterified analogue precursors were obtained by nucleophilic substitution of various halomethacrylate derivatives with trialkyl phosphites.Substitution of the halomethacrylates can occur either α to the leaving halogen or in the γ position with subsequent allylic shift of the double bond.The course of the reaction was influenced both by reaction conditions and the nature of the substituents on the reactants.The phosphonomethacrylates obtained were hydrolysed to PEP analogues that were found to be moderate to good inhibitors of PEP carboxylase.Phosphonomethacrylic acid derivatives bearing two halogen substituents in the γ position were found to be the most potent inhibitors of this enzyme.
