126429-21-8 Usage
Phophorylating Reagent
Diallyl N,N-diisopropylphosphoramidite was employed as a phophorylating reagent. It can be used for reactions involved in phosphitylation of alcohols, deallylation for the synthesis of nucleoside phosphoramidite, posphitylation and stereoselective pudovik rearrangement. It can be used for preparation of peptide substrates, rhodamine dyes with phosphorylated CH2OH sites, and 3-[4-(bis-allyloxy- phosphoryloxy)-2(R)-hydroxy-3,3-dimethyl-butyrylamino]-thiopropionic acid-S-propylester and so on. It also involved in the synthesis of pharmacologically active molecules including selective orally active S1P1 agonists, water-soluble prodrugs of triazole CS-758 with antifungal activity, and fostriecin analogs as antitumor agents, and so on
Uses
Different sources of media describe the Uses of 126429-21-8 differently. You can refer to the following data:
1. Precursor involved in the synthesis of pharmacologically active molecules including:? ;Selective orally active S1P1 agonists1? ;Water-soluble prodrugs of triazole CS-758 with antifungal activity2? ;Fostriecin analogs as antitumor agents3Reactant involved in: ? ;Phosphitylation of alcohols4? ;Deallylation for the synthesis of nucleoside phosphoramidite5? ;Posphitylation and stereoselective Pudovik rearrangement6
2. Diallyl N,N-diisopropylphosphoramidite is a reagent used in the synthesis of Leustroducsin B that exhibits large variety of biological activities. It also acts as a reagent in the synthesis of water-soluble prodrugs of triazole CS-758 with antifungal activities.
3. Precursor involved in the synthesis of pharmacologically active molecules including:Selective orally active S1P1 agonistsWater-soluble prodrugs of triazole CS-758 with antifungal activityFostriecin analogs as antitumor agentsReactant involved in: Phosphitylation of alcoholsDeallylation for the synthesis of nucleoside phosphoramiditePosphitylation and stereoselective Pudovik rearrangement
Check Digit Verification of cas no
The CAS Registry Mumber 126429-21-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,2 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 126429-21:
(8*1)+(7*2)+(6*6)+(5*4)+(4*2)+(3*9)+(2*2)+(1*1)=118
118 % 10 = 8
So 126429-21-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H24NO2P/c1-7-9-14-16(15-10-8-2)13(11(3)4)12(5)6/h7-8,11-12H,1-2,9-10H2,3-6H3
126429-21-8Relevant articles and documents
BIS(ALLYLOXY)(DIISOPROPYLAMINO)PHOSPHINE AS A NEW PHOSPHINYLATION REAGENT FOR THE PHOSPHORYLATION OF HYDROXY FUNCTIONS
Bannwarth, Willi,Kueng, Erich
, p. 4219 - 4222 (2007/10/02)
Bis(allyloxy)(diisopropylamino)phosphine is a new phosphinylating agent which can be employed for an effective phosphorylation of hydroxy functions after activation by tetrazole followed by an oxidation step.The allyl protecting groups are removed afterwards with Pd(O)P(C6H5)3)4 leading to the corresponding phophorylated substrate.
