129706-46-3Relevant articles and documents
Lipoic acid analogs with enhanced pharmacological activity
Kates, Steven A.,Casale, Ralph A.,Baguisi, Alexander,Beeuwkes III, Reinier
, p. 505 - 512 (2014)
Lipoic acid (1,2-dithiolane-3-pentanoic acid) is a pharmacophore with unique antioxidant and cytoprotective properties. We synthesized a library based upon the condensation of natural and unnatural amino acids with the carboxylic acid moiety of lipoic acid. SAR studies were conducted using a cardiac ischemia-reperfusion animal model. Cytoprotective efficacy was associated with the R-enantiomer of the dithiolane. Potency of library compounds was dictated by the acidic strength of the adduct. α-N-[(R)-1,2-dithiolane-3-pentanoyl]- l-glutamyl-l-alanine, designated CMX-2043, was chosen for further pharmacologic evaluation.