130658-14-9 Usage
General Description
4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C13H21NO3. It is a tert-butyl ester derivative of 4-oxo-1,2,3,6,7,8-hexahydrocyclopenta[c]pyrrole-2-carboxylic acid. 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is often used in organic synthesis and medicinal chemistry as an intermediate for the preparation of various pharmaceutical and biologically active substances. It can also be employed as a reference standard in analytical chemistry and spectroscopy applications. The tert-butyl ester group in the molecule provides stability and chemical protection to the carboxylic acid functionality, making it an important building block in the synthesis of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 130658-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,6,5 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 130658-14:
(8*1)+(7*3)+(6*0)+(5*6)+(4*5)+(3*8)+(2*1)+(1*4)=109
109 % 10 = 9
So 130658-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-5-10(14)9(8)7-13/h8-9H,4-7H2,1-3H3
130658-14-9Relevant articles and documents
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres
Sheffler, Douglas J.,Nedelovych, Michael T.,Williams, Richard,Turner, Stephen C.,Duerk, Brittany B.,Robbins, Megan R.,Jadhav, Sataya B.,Niswender, Colleen M.,Jones, Carrie K.,Conn, P. Jeffrey,Daniels, R. Nathan,Lindsley, Craig W.
, p. 1062 - 1066 (2014/03/21)
This Letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free fraction, and modest CNS penetration. Moreover, enantioselective GlyT1 inhibition was observed, within this novel series and a number of other piperidine bioisosteric cores.
TRICYCLIC HETEROARYL PIPERAZINES, PYRROLIDINES AND AZETIDINES AS SEROTONIN RECEPTOR MODULATORS
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Page/Page column 25, (2008/06/13)
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydro
