101046-32-6

Basic information

• Product Name: (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one
• CAS NO: 101046-32-6
• Molecular Weight: 215.295
• Mol File: 101046-32-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one(101046-32-6)
• EPA Substance Registry System: (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one(101046-32-6)

Safety Data

• Hazardous Substances Data: 101046-32-6(Hazardous Substances Data)

Usage

General Description

"(1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one" is a compound with a complex chemical structure. It is an important intermediate in the synthesis of pharmaceuticals and organic compounds. (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one is known for its potential biological activity and can be used as a building block in the development of various drugs. It contains a bicyclic structure with a nitrogen atom, which gives it unique reactivity and properties that make it useful in medicinal chemistry. Additionally, the benzyl group attached to the nitrogen atom enhances its stability and pharmacological properties. Overall, "(1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one" has potential applications in pharmaceutical research and drug development.

Upstream product

• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 
• 930-30-3 cyclopent-2-enone 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 

Downstream Products

• 116237-03-7 (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>-oct-7-ene 
• 130658-14-9 tert-butyl (cis)-4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 
• 1229515-57-4 2,4-dichloro-N-(2-(1-methyl-1H-imidazol-4-sulfonyl)-octahydrocyclopenta[c]pyrrol-4-yl)-benzamide 
• 874949-32-3 (3aR,4R,6aS)-2-(phenylmethyl)octahydrocyclopenta[c]pyrrol-4-amine 
• 1384106-79-9 (R,E)-N-((3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)-2-methylpropane-2-sulfinamide 
• 1384106-78-8 (R,E)-N-((3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)-2-methylpropane-2-sulfinamide 
• 1228024-58-5 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide 
• 1228029-76-2 (3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-amine 
• 116237-11-7 (1S*,5S*,7R*,8R*)-8-(3-cyclohexyl-3-hydroxy-1-propenyl)-7-hydroxy-N-m-methoxycarbonylbenzoyl-3-azabicyclo<3.3.0>octane 
• 116237-13-9 (1S*,5S*,7R*,8R*)-N-m-carboxybenzoyl-8-(3-cyclohexyl-3-oxo-1-propenyl)-7-hydroxy-3-azabicyclo<3.3.0>octane 
• 116237-10-6 (1S*,5S*,7R*,8R*)-8-(3-cyclohexyl-3-oxo-1-propenyl)-7-hydroxy-N-m-methoxycarbonylbenzoyl-3-azabicyclo<3.3.0>octane 
• 116237-09-3 (1S*,5S*,7R*,8R*)-8-(3-hydroxy-1-octenyl)-7-hydroxy-N-m-methoxycarbonylbenzoyl-3-azabicyclo<3.3.0>octane 
• 116237-12-8 (1S*,5S*,7R*,8R*)-N-m-carboxybenzoyl-7-hydroxy-8-(3-hydroxy-1-octenyl)-3-azabicyclo<3.3.0>octane 
• 116237-08-2 (1S*,5S*,7R*,8R*)-7-hydroxy-N-m-methoxycarbonylbenzoyl-8-(3-oxo-1-octenyl)-3-azabicyclo<3.3.0>octane 

Relevant articles and documents

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres

This Letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free fraction, and modest CNS penetration. Moreover, enantioselective GlyT1 inhibition was observed, within this novel series and a number of other piperidine bioisosteric cores.

Prostanoids and related compounds. V. Synthesis of 6-aza-5-oxo-2,3,4-trinor-1,5-inter-m-phenylene prostacyclin derivatives

6-Aza-5-oxo-2,3,4-trinor-1,5-inter-m-phenylene prostacyclin derivatives were synthesized by use of 1,3-dipolar cycloaddition as a key step.

Trifluoroacetic Acid-Catalyzed 1,3-Cycloaddition of the Simplest Iminium Ylide Leading to 3- or 3,4-Substituted Pyrrolidines and 2,5-Dihydropyrroles

The 1,3-dipolar cycloaddition of an intermediary iminium ylide formed from N-benzyl-N-(methoxymethyl)trimethylsilylmethylamine to conjugated olefinic and acetylenic dipolarophiles in the presence of a catalytic amount of trifluoroacetic acid has been found to give 3- or 3,4-substituted pyrrolidines and 2,5-dihydropyrroles.