131-65-7 Usage
General Description
2,4-dihydro-3-methyl-2-phenethyl-3H-pyrazol-3-one, also known as Praziquantel, is a chemical compound used as an anthelmintic medication to treat parasitic worm infections. It is effective against a wide range of parasites, including tapeworms, flukes, and schistosomes. Praziquantel works by disrupting the integrity of the parasites' cell membranes, causing paralysis and death. It is commonly used in both human and veterinary medicine and is considered safe and effective when used as directed. However, like all medications, it can have side effects and should be used under the guidance of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 131-65-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131-65:
(5*1)+(4*3)+(3*1)+(2*6)+(1*5)=37
37 % 10 = 7
So 131-65-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O/c1-3-10-6-4-5-7-11(10)14-12(15)8-9(2)13-14/h4-7H,3,8H2,1-2H3
131-65-7Relevant articles and documents
Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid
Maclean, Mark A.,Diez-Cecilia, Elena,Lavery, Christopher B.,Reed, Mark A.,Wang, Yanfei,Weaver, Donald F.,Stradiotto, Mark
, p. 100 - 104 (2015/12/18)
N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.
