13582-93-9 Usage
Description
3,4-dihydro-2H-4-benzoxazine-2-carboxamide is a chemical compound that serves as a building block for the synthesis of various biologically active molecules. It is a member of the benzoxazine derivatives class, known for its potential pharmaceutical applications. 3,4-dihydro-2h-4-benzoxazine-2-carboxamide features a cyclic structure with a benzene ring fused to an oxazine ring and an amide functional group, which endows it with unique chemical properties. These properties make it a valuable component in drug discovery and development, as well as in the creation of organic compounds with potential therapeutic effects. The ongoing research into its biological activities and pharmacological potential highlights its importance in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
3,4-dihydro-2H-4-benzoxazine-2-carboxamide is used as a building block for the development of biologically active molecules due to its unique cyclic structure and functional group, which can be utilized in the synthesis of new drugs with potential therapeutic effects.
Used in Drug Discovery:
3,4-dihydro-2H-4-benzoxazine-2-carboxamide is used as a starting material in drug discovery for its potential to contribute to the creation of novel pharmaceutical compounds with therapeutic properties, given its chemical versatility and the possibility of further chemical modifications.
Used in Organic Compound Preparation:
3,4-dihydro-2H-4-benzoxazine-2-carboxamide is used as a component in the preparation of various organic compounds that may exhibit therapeutic effects, leveraging its chemical properties to enhance the pharmacological profiles of these compounds.
The specific applications of 3,4-dihydro-2H-4-benzoxazine-2-carboxamide in different industries or for particular uses are not detailed in the provided materials. However, based on its role as a building block for biologically active molecules and its potential pharmaceutical applications, it can be inferred that it may have uses in the development of new drugs and therapeutic agents across various medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 13582-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,8 and 2 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 13582-93:
(7*1)+(6*3)+(5*5)+(4*8)+(3*2)+(2*9)+(1*3)=109
109 % 10 = 9
So 13582-93-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2O2/c10-9(12)8-5-11-6-3-1-2-4-7(6)13-8/h1-4,8,11H,5H2,(H2,10,12)/t8-/m1/s1
13582-93-9Relevant articles and documents
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1
Spinck, Martin,Bischoff, Matthias,Lampe, Philipp,Meyer-Almes, Franz-Josef,Sievers, Sonja,Neumann, Heinz
, p. 5838 - 5849 (2021/06/01)
Sirtuins are signaling hubs orchestrating the cellular response to various stressors with roles in all major civilization diseases. Sirtuins remove acyl groups from lysine residues of proteins, thereby controlling their activity, turnover, and localization. The seven human sirtuins, SirT1-7, are closely related in structure, hindering the development of specific inhibitors. Screening 170,000 compounds, we identify and optimize SirT1-specific benzoxazine inhibitors, Sosbo, which rival the efficiency and surpass the selectivity of selisistat (EX527). The compounds inhibit the deacetylation of p53 in cultured cells, demonstrating their ability to permeate biological membranes. Kinetic analysis of inhibition and docking studies reveal that the inhibitors bind to a complex of SirT1 and nicotinamide adenine dinucleotide, similar to selisistat. These new SirT1 inhibitors are valuable alternatives to selisistat in biochemical and cell biological studies. Their greater selectivity may allow the development of better targeted drugs to combat SirT1 activity in diseases such as cancer, Huntington's chorea, or anorexia.
Synthesis of 2-(2-imidazolinyl)substituted 2,3-dihydro-4h-1,4-benzothiazine and 3,4-dihydro-2h-1,4-benzoxazines
Butler,Chapleo,Myers,Welbourn
, p. 177 - 181 (2007/10/02)
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