135904-71-1 Usage
General Description
H-D-Asp(OtBu)-OtBu · HCl is a chemical compound that consists of two components combined into a single structure. The first component, H-D-Asp(OtBu)-OtBu, is a derivative of aspartic acid with tert-butyl ester groups attached to the side chain. H-D-Asp(OtBu)-OtBu · HCl is often used in organic synthesis and as a building block for peptides. The second component, HCl, is hydrochloric acid in its salt form. When combined, the two components form a salt that is commonly used in chemical reactions and as a reagent in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 135904-71-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,9,0 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 135904-71:
(8*1)+(7*3)+(6*5)+(5*9)+(4*0)+(3*4)+(2*7)+(1*1)=131
131 % 10 = 1
So 135904-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO4.ClH/c1-11(2,3)16-9(14)7-8(13)10(15)17-12(4,5)6;/h8H,7,13H2,1-6H3;1H/t8-;/m1./s1
135904-71-1Relevant articles and documents
Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone
Nortcliffe, Andrew,Fleming, Ian N.,Botting, Nigel P.,O'Hagan, David
supporting information, p. 8343 - 8347 (2015/03/05)
A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was conjugated in three part constructs to RGD sequences and NO releasing heterocycles. In general the analogues showed integrin binding affinity comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines.
