438246-17-4Relevant academic research and scientific papers
METHOD OF MODULATING TIGIT AND PD-1 SIGNALLING PATHWAYS USING 1,2,4-OXADIAZOLE COMPOUNDS
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Page/Page column 66; 70, (2019/10/04)
The present invention relates to method of modulating TIGIT signaling pathway and PD-1 signaling pathway. The invention also encompasses the use of the compound of formula (I) or a stereoisomer thereof or a pharmaceutically acceptable salt thereof for the treatment of diseases or disorders mediated by both TIGIT signaling pathway and PD-1 signaling pathway.
COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY
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Page/Page column 74, (2018/03/28)
The present invention relates to compound of formula (I) as therapeutic agents to modulate the TIGIT signalling pathway. The invention also encompasses the use of the compound of formula (I) or a stereoisomer thereof or a pharmaceutically acceptable salt thereof for the treatment of diseases or disorders mediated by TIGIT.
In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates
Kim, Mi Kyoung,Park, Kwang-su,Yeo, Woon-seok,Choo, Hyunah,Chong, Youhoon
experimental part, p. 1164 - 1171 (2009/07/11)
In order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin-amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and
