136982-89-3 Usage
Explanation
Different sources of media describe the Explanation of 136982-89-3 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Pyrimidine is a heterocyclic aromatic organic compound with the formula C4H4N2. This compound is derived from the pyrimidine ring, indicating its structure and potential chemical properties.
3. The hydroxymethyl group is attached to the dioxolane ring, providing additional functional groups and potential reactivity.
4. The methyl group is attached to the pyrimidine ring, further modifying the compound's structure and properties.
5. Chirality refers to the presence of a chiral center, which is an atom bonded to four different groups. In this case, the compound has two chiral centers, which can lead to different stereoisomers.
6. The compound's structure and functional groups suggest that it could have potential uses in drug development or other biological applications, but further research is needed to confirm these possibilities.
7. While the compound's structure and functional groups provide some insight into its potential properties and applications, more research is required to fully understand its characteristics and potential uses.
Pyrimidine derivative
A compound derived from the pyrimidine ring structure.
Dioxolane group
A five-membered ring containing two oxygen atoms.
Hydroxymethyl group
A functional group with the formula -CH2OH.
Methyl group
A functional group with the formula -CH3.
Chirality
The compound has two chiral centers at the 2R and 4R positions.
Potential pharmaceutical or biological applications
The compound's unique structure and functional groups may have applications in the pharmaceutical or biological fields.
Further research needed
The specific properties and potential uses of the compound are not yet fully understood.
Check Digit Verification of cas no
The CAS Registry Mumber 136982-89-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,9,8 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 136982-89:
(8*1)+(7*3)+(6*6)+(5*9)+(4*8)+(3*2)+(2*8)+(1*9)=173
173 % 10 = 3
So 136982-89-3 is a valid CAS Registry Number.
136982-89-3Relevant articles and documents
2-Substituted-4-substituted-1,3-dioxolanes and use thereof
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Page column 51 -52, (2010/11/29)
Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include: cis-2-acetoxymethyl-4-(thymin-1′-yl)-1,3,-dioxolane, cis-2-hydroxymethyl-4-(thymin-1′-yl)-1,3-dioxolane, cis-2-benzoyloxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane, and cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane. These compounds can be in the form of their racemates or their separate enantiomers.
Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues
Evans, Colleen A.,Dixit, Dilip M.,Siddiqui, M. Arshad,Jin, Haolun,Tse, H. L. Allan,et al.
, p. 2319 - 2322 (2007/10/02)
Oxidative degradation of benzyloxymethylacetals derived from D-mannitol or L-ascorbic acid provides dioxolane intermediate 6 and 7 useful in the synthesis of all the stereoisomers of dioxolane nucleoside analogues.
Asymmetric Synthesis of 1,3-Dioxolane-Pyrimidine Nucleosides and Their Anti-HIV Activity
Kim, Hea O.,Ahn, Soon K.,Alves, Antonio J.,Beach, J. Warren,Jeong, Lak S.,et al
, p. 1987 - 1995 (2007/10/02)
In order to study the structure-activity relationships of dioxolane nucleosides as potential anti-HIV agents, various enantiomerically pure dioxolane-pyrimidine nucleosides have been synthesized and evaluated against HIV-1 in human peripheral blood mononuclear cells.The enantiomerically pure key intermediate 8 has been synthesized in nine steps from 1,6-anhydro-D-mannose (1), which was condensed with 5-substituted pyrimidines to obtain various dioxolane-pyrimidine nucleosides.Upon evaluation of these compounds, cytosine derivative 19 was found to exhibit the most potent anti-HIV agent although it is the most toxic.The order of anti-HIV potency was as follows: cytosine (β-isomer) > thymine > cytosine (α-isomer) > 5-chlorouracil > 5-bromouracil > 5-fluorouracil derivatives.Uracil, 5-methylcytosine, and 5-iodouracil derivatives were found to be inactive.Interestingly, α-isomer 20 showed good anti-HIV activity without cytotoxicity.As expected, other α-isomers did not exhibit any significant antiviral activity. (-)-Dioxolane-T was 5-fold less effective against AZT-resistant virus than AZT-sensitive virus.
