137897-87-1 Usage
Chemical structure
The compound has a complex chemical structure with a dihydropyrimidin-4(1H)-one core, a propyl and phenylsulfanyl substituent, and a hydroxyethoxy group attached to a methyl group.
Heterocyclic structure
The compound has a heterocyclic structure, which is commonly found in drugs and may have potential pharmaceutical applications.
Thioxo group
The presence of a thioxo group in the compound suggests that it may have potential as a drug candidate for further research and development.
Hydroxyethoxy moiety
The presence of a hydroxyethoxy moiety in the compound may contribute to its potential as a drug candidate.
Potential applications
Due to its complex structure and heterocyclic nature, the compound may have potential pharmaceutical applications and could be a candidate for further research and development.
Molecular weight
The molecular weight of the compound is approximately 344.43 g/mol.
Solubility
The compound may have varying solubility in different solvents, depending on its specific properties and the solvents used.
Stability
The stability of the compound may depend on factors such as temperature, pH, and exposure to light or air.
Synthesis
The compound may be synthesized through various chemical reactions and techniques, depending on the specific requirements and desired outcome.
Characterization
The compound can be characterized using various analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and infrared (IR) spectroscopy.
Biological activity
The compound may exhibit various biological activities, depending on its specific properties and the target organism or cell type.
Toxicity
The toxicity of the compound may vary depending on factors such as dosage, route of administration, and the specific organism or cell type exposed to the compound.
Patentability
The compound may be patentable, depending on its novelty, non-obviousness, and utility in a specific application or field.
Regulatory considerations
The compound may be subject to regulatory considerations, such as safety and efficacy testing, before it can be used in pharmaceutical applications or other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 137897-87-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,8,9 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 137897-87:
(8*1)+(7*3)+(6*7)+(5*8)+(4*9)+(3*7)+(2*8)+(1*7)=191
191 % 10 = 1
So 137897-87-1 is a valid CAS Registry Number.
137897-87-1Relevant articles and documents
Structure-Activity Relationships of 1--6-(phenylthio)thymine Analogues: Effect of Substitutions at the C-6 Phenyl Ring and at the C-5 Position on Anti-HIV-1 Activity
Tanaka, Hiromichi,Takashima, Hideaki,Ubasawa, Masaru,Sekiya, Kouichi,Nitta, Iasei,et al.
, p. 337 - 345 (2007/10/02)
The effect of substitution on the pyrimidine moiety of 1--6-(phenylthio)thymine (HEPT) and 1--6-(phenylthio)-2-thiothymine (HEPT-S) on anti-HIV-1 activity was investigated by synthesizing a series of 5-methyl-6-(arylthio) and 5-substituted-6-(phenylthio) derivatives.Preparation of the 5-methyl-6-(arylthio) derivatives was carried out based on either LDA lithiation of 1-methyl>thymine (3) and 1-methyl>-2-thiothymine (4) followed by reaction with diaryl disulfides or an addition-elimination reaction of 1-methyl>-6-(phenylsulfinyl)thymine (31) with aromatic thiols.Preparation of the 5-substituted-6-(phenylthio) derivatives was carried out based on either C-5 lithiation of the 1-methyl>-6-(phenylthio)uracil (41) with LTMP or the LDA lithiation of 5-alkyl-1-methyl>-2-thiouracil derivatives 45-47.Substitution at the meta position of the C-6-(phenylthio) ring by the methyl group improved the original anti-HIV-1 activity of HEPT, and introduction of two m-methyl groups to the phenylthio ring further potentiated the activity -1-thymine (28), 0.26 μM; 6--1--2-thiothymine (30), 0.22 μM>.When the 5-methyl group was replaced by an ethyl or an isopropyl group, the anti-HIV-1 activity of HEPT was also improved remarkably -6-(phenylthio)-2-thiouracil (48), 0.11 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (50), 0.059 μM; 5-ethyl-1--6-(phenylthio)-2-thiouracil (54), 0.12 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (56), 0.063 μM>. 6--5-ethyl-1-thymine derivatives 51 and 57 and 6--5-isopropyl-1-thymine derivatives 52 and 58 inhibited the replication of HIV-1 in the nanomolar concentration range.
