139122-81-9 Usage
Description
Tripterifordin, also known as a kaurane diterpenoid, is a compound isolated from the roots of Tripterygium wilfordii. It is characterized by its unique chemical structure, with a hydroxy group at position 16 and exhibits anti-HIV activity. Tripterifordin is a promising pharmaceutical candidate due to its potential therapeutic properties.
Uses
Used in Pharmaceutical Industry:
Tripterifordin is used as an anti-HIV agent for its ability to inhibit the replication of the human immunodeficiency virus (HIV). It has shown potential in modulating the virus's life cycle and reducing the viral load in infected individuals.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, tripterifordin's potential as an anticancer agent could be explored due to its ability to modulate various signaling pathways, similar to gallotannin. Further research would be required to confirm its efficacy and safety in this application.
Used in Drug Delivery Systems:
Tripterifordin could also be used in the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the delivery, efficacy, and targeting of tripterifordin to specific cells or tissues could be improved.
Check Digit Verification of cas no
The CAS Registry Mumber 139122-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,1,2 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 139122-81:
(8*1)+(7*3)+(6*9)+(5*1)+(4*2)+(3*2)+(2*8)+(1*1)=119
119 % 10 = 9
So 139122-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O3/c1-17-7-3-8-20(12-23-16(17)21)14(17)6-9-19-10-13(4-5-15(19)20)18(2,22)11-19/h13-15,22H,3-12H2,1-2H3/t13-,14-,15?,17?,18-,19+,20+/m1/s1
139122-81-9Relevant articles and documents
Syntheses of (-)-Tripterifordin and (-)-Neotripterifordin from Stevioside
Kobayashi, Shoji,Shibukawa, Keisuke,Hamada, Yoshiki,Kuruma, Takuma,Kawabata, Asako,Masuyama, Araki
, p. 1606 - 1613 (2018)
We report short syntheses of (-)-tripterifordin and (-)-neotripterifordin, potent inhibitors of HIV replication, from stevioside, a natural sweetener used worldwide. The key transformations are reduction at C13 through the formation of a tertiary chloride and subsequent three-step lactonization including a selective iodination at C20 by the photoreaction of the C19-alcohol. The title compounds were reliably obtained from stevioside in 9 and 11 steps (with 5-7 isolation steps), respectively. Additionally, the related lactone-containing ent-kaurenes, doianoterpenes A and B, and two more natural products were synthesized.