1421-86-9 Usage
Description
Strychnine Hydrochloride is a chemical compound derived from the combination of strychnine with one molar equivalent of hydrogen chloride. It is known for its potent antagonistic properties against various receptors and aggregation processes.
Uses
Used in Pharmaceutical Applications:
Strychnine Hydrochloride is used as a cholinesterase antagonist for the inhibition of cholinesterases, which are enzymes that break down acetylcholine, a neurotransmitter. This application is crucial in certain medical treatments where the preservation of acetylcholine is necessary.
Used in Neurobiology Research:
In the field of neurobiology, Strychnine Hydrochloride is used as a glycine receptor antagonist in the retina. It plays a significant role in studying the biophysiological functions of these receptors and their interactions with other neurotransmitter systems.
Used in Retinal Studies:
Strychnine Hydrochloride is also utilized to block glutamatergic, GABAergic, and glycinergic receptors, as well as gap junctions in the retina. This allows researchers to investigate the roles of these receptors and their interactions in various retinal processes and functions.
Biological Activity
Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α 7 receptors and non-competitive antagonism at α 4 β 2 receptors.
Biochem/physiol Actions
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
Check Digit Verification of cas no
The CAS Registry Mumber 1421-86-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1421-86:
(6*1)+(5*4)+(4*2)+(3*1)+(2*8)+(1*6)=59
59 % 10 = 9
So 1421-86-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19?,20-,21+;/m0./s1
1421-86-9Relevant articles and documents
Structural and chiroptical analysis of naturally occurring (-)-strychnine
Reinscheid,Schmidt,Abromeit,Liening,Scriba,Reinscheid
, p. 200 - 209 (2015/11/18)
Structural aspects such as chemical exchange, dimerization, solvent association, nitrogen inversion and protonation status of strychnine were investigated using experimental and calculated data. The information was mainly interpreted in view of a successful determination of the absolute configuration (AC) with strychnine (base and salt) as test molecule due to its importance in chemistry. By geometry optimization a stable isomer of protonated strychnine was found with an inverted nitrogen, however, 25 kcal/mol higher in energy. It is shown that solvent association can be assumed in protic solvents such as methanol and dimerization to a small extent in polar/protic solvents. However, the monomeric structural model neglecting explicit solvent molecules still allows the correct prediction of the AC of base and hydrochloride using optical rotation and ECD data.
