14341-86-7 Usage
Description
SUCCINIC-D4 ANHYDRIDE is a chemical compound that is utilized in the synthesis of various derivatives and serves as a reagent for developing novel inhibitors. It is a deuterated form of succinic anhydride, which is a four-carbon dicarboxylic anhydride.
Uses
Used in Pharmaceutical Industry:
SUCCINIC-D4 ANHYDRIDE is used as a synthetic intermediate for the production of propanoyloxy derivatives, which function as drug absorption modifiers. These derivatives enhance the bioavailability and absorption of certain drugs, thereby improving their overall effectiveness.
Used in Research and Development:
SUCCINIC-D4 ANHYDRIDE serves as a reagent for the development of novel non-carboxylate inhibitors of AKR1C3, an enzyme involved in various biological processes. By inhibiting this enzyme, researchers can study its role in different pathways and potentially develop new therapeutic strategies for related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14341-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,4 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14341-86:
(7*1)+(6*4)+(5*3)+(4*4)+(3*1)+(2*8)+(1*6)=87
87 % 10 = 7
So 14341-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H4O3/c5-3-1-2-4(6)7-3/h1-2H2/i1D2,2D2
14341-86-7Relevant articles and documents
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McLean,Adams
, p. 804,806 (1936)
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Degenerate Thermal Rearrangement of 1,3-Dimethylenecyclopentane. Evidence for Partially Stereospecific Biradical Formation and Closure in 1,3 Shift
Gajewski, Joseph J.,Salazar, Jose Del C.
, p. 4145 - 4154 (2007/10/02)
Parolysis of 1,3-bis(dideuteriomethylene)cyclopentane at 370 deg C resulted in a first-order degenerate rearrangement in which the 1,3- and 3,3-shift products were formed in a 2:1 ratio, respectively, indicating the intermediacy of an effectively orthogonal 2,2'-bis(allylmethane) biradical.Pyrolysis of trans- and cis-4,5-dimethyl-1,3-dimethylenecyclopentane (T and C) gave 1,3- and 3,3-shift products with stereochemistry consistent with predominant conrotatory-bevel ring opening to produce the orthogonal diradical directly.Pyrolysis of optically active T gave the 1,3-shift products with 20.8percent inversion of configuration of the migrating carbon indicative of partial stereospecific closure of the biradical.Comparative pyrolysis of optically active T and its bis(dideuteriomethylene) derivative revealed no secondary kinetic deuterium isotop effect, but an alternation in the extent of racemization of starting material and amounts of 1,3- and 3,3-shift products indicates a product-determining isotope effect.These data provide further evidence for an intermediate.