14446-75-4Relevant articles and documents
HYDROGENATION PROCESS
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Page/Page column 27-28, (2020/01/24)
A process for the production of heterocyclic quaternary ammonium salts or hydroxides is disclosed. The process comprises a continuous hydrogenation step, in which an unsaturated heterocyclic amine is reacted with hydrogen to form a saturated heterocyclic amine; a first continuous N-alkylation step, in which the saturated heterocyclic amine is alkylated to produce an intermediate saturated heterocyclic amine having an increased degree of substitution compared to the saturated heterocyclic amine; and one or more further N-alkylation steps in which the intermediate saturated heterocyclic amine is N-alkylated to the heterocyclic quaternary ammonium salt or hydroxide. A process of producing a saturated heterocyclic amineis also disclosed. The process comprises reacting an unsaturated heterocyclic amine with hydrogen in a vapour phase reaction at a pressure of not more than 70 bar and a temperature in the range of from 150°C to 350°C. A process of N-alkylating a saturated heterocyclic amine is also disclosed. The process comprises N-alkylating the saturated heterocyclic amine in a vapour phase reaction at a temperature of at least 2°C.
Preparation method of high-purity cis-3,5-dimethylpiperidine
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Paragraph 0038-0040, (2017/08/30)
The invention relates to a preparation method of high-purity cis-3,5-dimethylpiperidine, and belongs to the field of organic synthesis. According to the preparation method, 3,5-dimethyl pyridine is taken as a raw material, a 3,5-dimethylpiperidine crude product is obtained via catalytic hydrogenation, and high-purity cis-3,5-dimethylpiperidine is obtained via precipitation purifying, wherein the cis gas chromatographic purity is larger than 99.5%. in the preparation method, neutral aluminium oxide and an alkali are introduced, and the combination mode of pyridine molecules with catalyst molecules in hydrogenation process is changed, so that it is beneficial for formation of cis-form products, and the crude product which can be applied in drug production directly is obtained; the cis-isomeride with a purity higher than 99.5% after treatment is obtained for the first time in the field of cis synthesis and separation of 3,5-dimethylpiperidine, and great referential significance and relatively high commerical value in the fields of synthesis purification and industrialized production of piperidine derivatives are achieved.
C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
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, (2008/06/13)
C-20-Dihydro-deoxy-(cyclic amino)-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.
