146285-52-1Relevant articles and documents
Design and fast synthesis of C-terminal duplicated potent C2-symmetric P1/P1'-modified HIV-1 protease inhibitors
Alterman, Mathias,Andersson, Hans O.,Garg, Neeraj,Ahlsén, G?ran,L?vgren, Seved,Classon, Bj?rn,Danielson, U. Helena,Kvarnstr?m, Ingmar,Vrang, Lotta,Unge, Torsten,Samuelsson, Bertil,Hallberg, Anders
, p. 3835 - 3844 (1999)
An analysis of the X-ray structure of a complex of HIV-1 protease with a linear C2-symmetric C-terminal duplicated inhibitor guided the selection of a series of diverse target compounds. These were synthesized with the objective to identify sui
A Simple Method for the Preparation of Stainless and Highly Pure Trichloroacetimidates
Ikeuchi, Kazutada,Murasawa, Kentaro,Yamada, Hidetoshi
supporting information, p. 1308 - 1312 (2019/06/20)
We describe a method for obtaining various allylic, benzylic, and glucosyl 2,2,2-trichloroacetimidates (TCAIs) as stainless liquids or solids at the crude stage. The general synthetic method for the preparation of TCAIs often leads to stained products, and further purification of crude TCAIs causes decomposition due to their instability. In the described method, we use a solvent that barely dissolves the reactant, providing stainless and sufficiently pure TCAIs without requiring a purification step. Furthermore, the reaction mixture is turbid at the beginning and clear at the end, allowing us to monitor the progress of the reaction visually.
Gold(I)-catalyzed arylmethylation of terminal alkynes
Li, Changkun,Li, Weibin,Wang, Jianbo
supporting information; experimental part, p. 2533 - 2535 (2009/07/26)
AuCl/AgOTf catalyzes the reaction of terminal alkynes with aryl trichloroacetimidate to afford arylmethylation products in moderate to good yields.