152028-96-1

Basic information

• Product Name: iodoproxyfan
• Synonyms: iodoproxyfan
• CAS NO: 152028-96-1
• Molecular Formula: C₁₃H₁₅IN₂O
• Molecular Weight: 342.174
• Mol File: 152028-96-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 464.2°Cat760mmHg
• Flash Point: 234.6°C
• Appearance: /
• Density: 1.584g/cm³
• Vapor Pressure: 2.36E-08mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: iodoproxyfan(CAS DataBase Reference)
• NIST Chemistry Reference: iodoproxyfan(152028-96-1)
• EPA Substance Registry System: iodoproxyfan(152028-96-1)

Safety Data

• Hazardous Substances Data: 152028-96-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)

Upstream product

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Relevant articles and documents

Iododestannylation: An Improved Synthesis of Iodoproxyfan, a Specific Radioligand of the Histamine H3 Receptor

Iodoproxyfan, a specific radioligand of histamine H3 receptors, was synthesized in 60percent yield under very mild conditions from a tributylstannyl precursor.The arylstannane, which was obtained in a palladium-catalyzed reaction of arylbromide and hexabutylditin, smoothly underwent radioiodination with sodium iodide and chloramine-T to give tritylated iodoproxyfan.Final detritylation was achieved with formic acid 90percent at room temperature.Compared to the original copper(I)-mediated halogen exchange this procedure has major advantages in terms of cost and ease of use. - Key Words: Iodine-125; iododestannylation; iodoproxyfan; histamine H3 receptor antagonist.

Imidazole compounds and their therapeutic applications

A compound selected from the group consisting of a compound of the formulawherein the substituents are defined as in the specification having antagonist properties to histamine H3-receptors.