14743-81-8

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• Basic information

  1. Product Name: 4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide
  2. Synonyms: 4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide
  3. CAS NO:14743-81-8
  4. Molecular Formula: C₁₈H₁₄ClNO₃S
  5. Molecular Weight: 359.82666
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 14743-81-8.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide(CAS DataBase Reference)
  10. NIST Chemistry Reference: 4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide(14743-81-8)
  11. EPA Substance Registry System: 4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide(14743-81-8)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 14743-81-8(Hazardous Substances Data)

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• Benzenesulfonamide, 4-chloro-N-(4-phenoxyphenyl)-

  Cas No: 14743-81-8

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• Benzenesulfonamide, 4-chloro-N-(4-phenoxyphenyl)- CAS No 14743-81-8

  Cas No: 14743-81-8

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14743-81-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 14743-81-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,4 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14743-81:
(7*1)+(6*4)+(5*7)+(4*4)+(3*3)+(2*8)+(1*1)=108
108 % 10 = 8
So 14743-81-8 is a valid CAS Registry Number.

14743-81-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-chloro-N-(4-phenoxyphenyl)benzenesulfonamide

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14743-81-8 SDS

14743-81-8Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 139-59-3 4-phenoxyanilin 

14743-81-8Downstream Products

14743-81-8Relevant articles and documents

Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists

Yamada, Ayumi,Kazui, Yuko,Yoshioka, Hiromasa,Tanatani, Aya,Mori, Shuichi,Kagechika, Hiroyuki,Fujii, Shinya

supporting information, p. 1028 - 1033 (2016/12/16)

We report here development of N-(4-phenoxyphenyl)benzenesulfonamide derivatives as a novel class of nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiological systems, including the female reproductive system, and PR antagonists are candidates for clinical treatment of multiple diseases, including uterine leiomyoma, endometriosis, breast cancer, and some psychiatric disorders. We found that the benzenesulfonanilide skeleton functions as a novel scaffold for PR antagonists, and we adopted 3-chlorobenzenesulfonyl derivative 20a as a lead compound for structural development. Among the synthesized compounds, 3-trifluoromethyl derivative 32 exhibited the most potent PR-antagonistic activity, with high binding affinity for PR and selectivity over androgen receptor (AR). It is structurally distinct from other nonsteroidal PR antagonists, including cyanopyrrole derivatives, and further modification is expected to afford novel selective PR modulators.

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