149303-38-8 Usage
Description
FMOC-BETA-ALA-OPFP, also known as Fmoc-protected alanine derivative, is a chemical compound used in the synthesis of various molecules. It is characterized by its white powder appearance and is a crucial component in the development of novel bioactive molecules.
Uses
Used in Pharmaceutical Industry:
FMOC-BETA-ALA-OPFP is used as a reagent for the synthesis of benzophenone-peptide nucleic acids (PNA) derivatives. These derivatives are specifically designed for mitochondrial targeting, which is an essential aspect in the development of new therapeutic strategies against various diseases.
Additionally, FMOC-BETA-ALA-OPFP can be employed in the synthesis of other bioactive molecules, contributing to the advancement of drug discovery and development in the pharmaceutical industry. Its Fmoc protection allows for selective deprotection and coupling reactions, making it a versatile building block in the synthesis of complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 149303-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,3,0 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 149303-38:
(8*1)+(7*4)+(6*9)+(5*3)+(4*0)+(3*3)+(2*3)+(1*8)=128
128 % 10 = 8
So 149303-38-8 is a valid CAS Registry Number.
149303-38-8Relevant articles and documents
Solution phase synthesis of β-peptides using micro reactors
Watts, Paul,Wiles, Charlotte,Haswell, Stephen J,Pombo-Villar, Esteban
, p. 5427 - 5439 (2007/10/03)
The synthesis of β-peptides has been successfully performed using a borosilicate glass micro reactor, in which a network of channels has been produced using a photolithographic and wet etching method. The reagents were mobilised by electroosmotic flow (EOF). The micro reactor was initially evaluated using a carbodiimide coupling reaction to form a dipeptide. The methodology has been extended such that the peptides may also be produced via the pentafluorophenyl ester derivatives of amino acids. It was found that performing the pentafluorophenyl ester reactions in the micro reactor resulted in an increase in the reaction efficiency over the traditional batch method. We postulate that the enhancement in rate of reaction is an electrochemical phenomenon, due to the reaction being performed in an electric field, which is unique to micro reactor systems. It has also been demonstrated that selective deprotection of the resultant dipeptides can be achieved. This approach has been used in the synthesis of a tripeptide.