150639-34-2Relevant articles and documents
New chiral bis(oxazoline) Rh(I)-, Ir(I)- and Ru(II)-complexes for asymmetric transfer hydrogenations of ketones
Debono, Nathalie,Besson, Michèle,Pinel, Catherine,Djakovitch, Laurent
, p. 2235 - 2238 (2004)
Chiral bis(oxazoline)-based Rh(I)-, Ir(I)- and Ru(II)-complexes have been prepared and used for asymmetric transfer hydrogenation of prochiral ketones. The presence of a free hydroxyl group on the ligand is necessary for high enantioselectivity. With acetophenone, up to 50% conversion and 89% ee were achieved.
Nickel/bis(oxazoline)-catalyzed asymmetric Kumada reactions of alkyl electrophiles: Cross-couplings of racemic α-bromoketones
Lou, Sha,Fu, Gregory C.
supporting information; experimental part, p. 1264 - 1266 (2010/04/01)
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Heterogeneous asymmetric nitro-Mannich reaction using a bis(oxazoline) ligand grafted on mesoporous silica
Lee, Anna,Kim, Woosung,Lee, Jinwoo,Hyeon, Taeghwan,Kim, B. Moon
, p. 2595 - 2598 (2007/10/03)
A chiral bis(oxazoline) ligand was immobilized on mesoporous silica (SBA-15) and examined in an asymmetric heterogeneous nitro-Mannich reaction. Depending upon the size of the alkyl chain in the nitroalkane substrates, enantioselectivities comparable to and higher diastereoselectivities (syn/anti ratio) than those obtained from homogeneous reactions were observed. In the case of the long chain substituted nitroalkane substrate (nitrohexane), the best selectivities (diastereoselectivity: syn/anti = 98/2, and enantioselectivity: 93% and 82% ee's for syn- and anti-isomers, respectively), were observed. Recycling of the catalyst in subsequent reactions was carried out and gradually diminishing levels of both diastereo and enantioselectivities were observed after each recycle.