10344-69-1

Basic information

• Product Name: DIETHYL MALONIMIDATE DIHYDROCHLORIDE
• Synonyms: MALONODIIMIDIC ACID DIETHYL ESTER HYDROCHLORIDE;DIETHYL MALONIMIDATE DIHYDROCHLORIDE;DIETHYLMALONDIIMIDATE DIHYDROCHLORIDE;propanediimidicacid,diethylester,dihydrochloride;DIETHYL MALONIMIDATE DIHYDROCHLORIDE, 97 %;Propanediimidic acid, 1,3-diethyl ester, hydrochloride (1:2)
• CAS NO: 10344-69-1
• Molecular Formula: C₇H₁₄N₂O₂*2ClH
• Molecular Weight: 231.12
• EINECS: 248-400-6
• Product Categories: Amidates/Imidates;Nitrogen Compounds;Organic Building Blocks
• Mol File: 10344-69-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 122 °C (dec.)(lit.)
• Boiling Point: 171.8 °C at 760 mmHg
• Flash Point: 57.7 °C
• Appearance: WHITE TO YELLOW POWDER OR CRYSTALLINE POWDER
• Density: g/cm³
• Vapor Pressure: 0.688mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: DIETHYL MALONIMIDATE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL MALONIMIDATE DIHYDROCHLORIDE(10344-69-1)
• EPA Substance Registry System: DIETHYL MALONIMIDATE DIHYDROCHLORIDE(10344-69-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 10344-69-1(Hazardous Substances Data)

Usage

Uses

Reactant for:Preparation of rhenium cyanobis(oxazoline) oxo complexes as enantioselective reduction catalystsSynthesis of chiral bis(oxazoline)-copper complexes immobilized by donor-acceptor interactions on insoluble organic supports as reusable catalysts for asymmetric Diels-Alder cycloadditionPreparation of nonracemic bis(oxazoline)ruthenium p-cymene complexes and silica-supported analogs as catalysts for the enantioselective transfer hydrogenation of ketones to secondary alcohols

InChI:InChI=1/C7H13NO3/c1-3-10-6(8)5-7(9)11-4-2/h8H,3-5H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 109-77-3 malononitrile 

Downstream Products

• 7597-56-0 ethyl malonamate 
• 42003-88-3 ethyl 2-cyanoacetimidate 
• 105-53-3 diethyl malonate 
• 75-00-3 chloroethane 
• 108-13-4 malonodiamide 
• 107303-15-1 N,N',N',N''-Tetraphenaethyl-malonsaeure-diamidin 
• 133463-87-3 (-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol) 
• 132098-59-0 (S,S)-2,2'-methylenebis(4-phenyl-2-oxazoline) 
• 175166-49-1 [3aS-[2(3'aR*,8'aS*),3a,8a]]methylenebis[3a,8a-dihydro-8H-indeno[1,2-d]oxazole] 
• 1331965-71-9 C₂₅H₃₀F₂N₄ 
• 936247-79-9 C₂₇H₃₆N₄ 
• 1453106-62-1 bis((4R,5S)-4-(bromomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane 
• 1453106-63-2 bis((4S,5S)-4-(azidomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane 

Relevant articles and documents

CuII/TEMPO-Catalyzed Enantioselective C(sp3)–H Alkynylation of Tertiary Cyclic Amines through Shono-Type Oxidation

A novel strategy for asymmetric Shono-type oxidative cross-coupling has been developed by merging copper catalysis and electrochemistry, affording C1-alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co-catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported.

Synthesis of C2-symmetric bisamidines: A new type of chiral metal-free lewis acid analogue interacting with carbonyl groups

(Chemical Equation Presented) The chiral bisamidine 5 has been prepared in just two steps from malonodinitrile. In the monocationic form this compound adopts a planar conformation with an almost convergent orientation of two N-H groups. Ketones, aldehydes

PROCESS FOR SYNTHESIS OF PICOLINAMIDES

The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.

Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.