15265-28-8 Usage
Description
Palitantin is a fungal metabolite, originally isolated from P. palitans, which possesses significant antifungal and antiprotozoal properties. It has been recognized for its ability to inhibit HIV-1 integrase, demonstrating its potential in the field of pharmaceuticals. With IC50 values of 350 and 268 μM for 3’-processing and strand transfer activity, respectively, palitantin serves as a valuable standard for the dereplication of natural products.
Uses
Used in Antifungal Applications:
Palitantin is utilized as an antifungal agent, effective against various fungal infections. Its potent antifungal properties make it a crucial component in the development of treatments for a range of fungal diseases.
Used in Antiprotozoal Applications:
In addition to its antifungal capabilities, palitantin also serves as an antiprotozoal compound. It is used to combat protozoan infections, which can be particularly beneficial in areas where such infections are prevalent.
Used in HIV-1 Inhibition:
Palitantin is employed as an inhibitor of HIV-1 integrase, playing a significant role in the development of treatments for HIV and AIDS. Its ability to inhibit the 3’-processing and strand transfer activity of HIV-1 integrase with IC50 values of 350 and 268 μM, respectively, makes it a promising candidate for further research and pharmaceutical applications.
Used in Pharmaceutical Research:
As a standard for dereplication of natural products, palitantin is used in the pharmaceutical industry to identify and characterize novel compounds with similar properties. This helps in the discovery of new drugs and therapeutic agents, contributing to the advancement of medical science.
Check Digit Verification of cas no
The CAS Registry Mumber 15265-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,6 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 15265-28:
(7*1)+(6*5)+(5*2)+(4*6)+(3*5)+(2*2)+(1*8)=98
98 % 10 = 8
So 15265-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H22O4/c1-2-3-4-5-6-7-10-8-12(16)14(18)13(17)11(10)9-15/h4-7,10-12,14-16,18H,2-3,8-9H2,1H3/b5-4+,7-6+/t10-,11+,12-,14-/m1/s1
15265-28-8Relevant articles and documents
THE BIOSYNTHESIS OF FULVIC ACID, A FUNGAL METABOLITE OF HEPTAKETIDE ORIGIN
Kurobane, Itsuo,Hutchinson, C. Richard,Vining, Leo C.
, p. 493 - 496 (2007/10/02)
Analyses of the regiochemistry of acetate incorporation into fulvic acid (2) by Penicillium brefeldianum indicates that the metabolite is biosynthesized via a heptaketide intermediate assembled as a single chain of seven C2 units rather than from two smaller polyketide chains.This information favours a route leading through common C14 intermediates to the three fungal metabolites, citromycetin, fulvic acid and fusarubin.