153254-09-2 Usage
Description
2,4-Bis(trifluoromethyl)phenylboronic acid is a white crystalline chemical compound that features a boron atom bonded to a phenyl ring with two trifluoromethyl groups attached at the 2nd and 4th positions. 2,4-Bis(trifluoromethyl)phenylboronic acid is known for its unique chemical properties and versatile applications in various industries.
Uses
Used in Pharmaceutical Industry:
2,4-Bis(trifluoromethyl)phenylboronic acid is used as a reactant for the preparation of various pharmaceutical compounds, such as:
Pyrrolo[2,3-d]pyrimidin-4-ones, which act as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor.
Biaryl pyrazole carboxamides, serving as sodium channel blockers for the treatment of neuropathic pain.
Biphenylketones, which function as dual modulators of inflammation and bone loss.
Used in Chemical Research:
In the field of chemical research, 2,4-Bis(trifluoromethyl)phenylboronic acid is utilized for the synthesis of:
(Biphenyl[3,4-c]pyrazol-5-yl)phenylcarboxamides, to study their voltage-gated sodium channel Nav1.7 blocking structure-activity relationship.
N-hydroxyalkyl biphenylsulfonamides, which are inhibitors of bone resorption.
1,3,6,8a-tetraazaacenaphthylene derivatives, to investigate their activity as corticotropin-releasing factor-1 antagonists.
Used in Material Science:
2,4-Bis(trifluoromethyl)phenylboronic acid is also used in the development of blue luminescent iridium phenylpyridine complexes, which have potential applications in the field of optoelectronics and lighting technology.
Check Digit Verification of cas no
The CAS Registry Mumber 153254-09-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,2,5 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 153254-09:
(8*1)+(7*5)+(6*3)+(5*2)+(4*5)+(3*4)+(2*0)+(1*9)=112
112 % 10 = 2
So 153254-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H5BF6O2/c10-7(11,12)4-1-2-6(9(16)17)5(3-4)8(13,14)15/h1-3,16-17H
153254-09-2Relevant articles and documents
2,6-Bis(trifluoromethyl)phenylboronic Esters as Protective Groups for Diols: A Protection/Deprotection Protocol for Use under Mild Conditions
Shimada, Naoyuki,Urata, Sari,Fukuhara, Kenji,Tsuneda, Takao,Makino, Kazuishi
, p. 6064 - 6068 (2018)
The application of 2,6-bis(trifluoromethyl)phenyl boronic acid (o-FXylB(OH)2; o-FXyl = 2,6-(CF3)2C6H3) as a recoverable and reusable protective agent for diols is described. The resulting cyclic boronic esters are water- and air-stable and tolerant to various organic transformations. Moreover, they can be deprotected under mild conditions. This methodology was applied to the synthesis of a highly conjugated enetriyne natural product with anti-angiogenic activities.
Crystalline pyridazine compound
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Page/Page column 7; 8, (2009/04/24)
A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.
