160096-59-3

• 

• Basic information

  1. Product Name: VERATRYLCURCUMINOID
  2. Synonyms: VERATRYLCURCUMINOID;Dimethoxycurcumin;(1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one;Dimethoxycurcumin(DiMC);Dimethoxycurcumin(DMC)
  3. CAS NO:160096-59-3
  4. Molecular Formula: C₂₃H₂₄O₆
  5. Molecular Weight: 396.43306
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 160096-59-3.mol
  9. Article Data: 15

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 587.007°C at 760 mmHg
  3. Flash Point: 254.399°C
  4. Appearance: /
  5. Density: 1.169g/cm³
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.585
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: VERATRYLCURCUMINOID(CAS DataBase Reference)
  11. NIST Chemistry Reference: VERATRYLCURCUMINOID(160096-59-3)
  12. EPA Substance Registry System: VERATRYLCURCUMINOID(160096-59-3)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 160096-59-3(Hazardous Substances Data)

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• SDS
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160096-59-3 Suppliers

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• Hot Sell Factory Supply Raw Material CAS 160096-59-3 ,Dimethoxycurcumin

  Cas No: 160096-59-3

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• 10 Kilogram

• 100 Metric Ton/Month

• Wuhan Han Sheng New Material Technology Co.，Ltd
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• VERATRYLCURCUMINOID CAS:160096-59-3

  Cas No: 160096-59-3

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• 1 Gram

• 3 Metric Ton/Month

• Qingdao Beluga Import and Export Co., LTD
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• 1,6-Heptadiene-3,5-dione,1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

  Cas No: 160096-59-3

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• 1 Kilogram

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• Shandong Hanjiang Chemical Co., Ltd.
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• 1,6-Heptadiene-3,5-dione,1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

  Cas No: 160096-59-3

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• 10000 Metric Ton/Month

• Henan Wentao Chemical Product Co., Ltd.
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• VERATRYLCURCUMINOID

  Cas No: 160096-59-3

• USD $ 10.0-100.0 / Kilogram

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• 1,6-Heptadiene-3,5-dione,1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

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• USD $ 100.0-100.0 / Gram

• 10 Gram

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• Zibo Hangyu Biotechnology Development Co., Ltd
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• Dimethoxycurcumin

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• USD $ 100.0-2000.0 / Gram

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• VERATRYLCURCUMINOID

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160096-59-3 Usage

Description

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities. It inhibits mitogen-induced proliferation of CD4+ T cells, CD8+ T cells, and B cells, as well as secretion of IL-2, IL-4, IL-6, and IFN-γ induced by concanavalin A in isolated human lymphocytes when used at concentrations ranging from 1 to 10 μM. Dimethoxycurcumin (1-10 μM) inhibits LPS-induced nitric oxide (NO) production and expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. It inhibits hemolysis of isolated human red blood cells (RBCs) induced by AAPH when used at a concentration of 10 μM.

Uses

dimethoxy Curcumin is an analog of curcumin more effective at suppressing HCT116 tumor cells than the parent compound.

Check Digit Verification of cas no

The CAS Registry Mumber 160096-59-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,0,9 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 160096-59:
(8*1)+(7*6)+(6*0)+(5*0)+(4*9)+(3*6)+(2*5)+(1*9)=123
123 % 10 = 3
So 160096-59-3 is a valid CAS Registry Number.

InChI:InChI=1/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-14H,15H2,1-4H3/b9-5+,10-6+

160096-59-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	Dimethoxycurcumin

1.2 Other means of identification

Product number	-
Other names	Di-O-methylchlordeoxydecarboxyphomazarin

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:160096-59-3 SDS

160096-59-3Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 123-54-6 acetylacetone 
• 458-37-7 curcumin 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 15001-27-1 O-methyldehydrozingerone 
• 39856-08-1 (E)-3,4-dimethoxycinnamic chloride 
• 111-30-8 Glutaraldehyde 

160096-59-3Downstream Products

• 52328-97-9 (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione 
• 1226895-15-3 FLLL₃₂ 
• 52328-98-0 O,O-dimethyl-curcumin 
• 1118765-37-9 (2E,6E)-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienamide 
• 1118765-35-7 (2E,6E)-methyl-7-(3,4-dimethoxyphenyl)-4-((E)-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienoate 
• 1118765-46-0 (E,E)-3,5-bis(3,4-dimethoxystyryl)isoxazole 
• 478919-25-4 (E,E)-3,5-bis(3,4-dimethoxystyryl)-1H-pyrazole 
• 1118765-36-8 (2E,6E)-ethyl-7-(3,4-dimethoxyphenyl)-4-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-oxohepta-2,6-dienoate 

160096-59-3Relevant articles and documents

Curcumin-Cu(II) Ensemble-Based Fluorescence "turn-On" Mode Sensing the Plant Defensive Hormone Salicylic Acid in Situ and in Vivo

Chen, Chong,Yang, Lin-Lin,Tang, A-Ling,Wang, Pei-Yi,Dong, Rong,Wu, Zhi-Bing,Li, Zhong,Yang, Song

, p. 4844 - 4850 (2020/05/01)

Salicylic acid (SA), a crucial, plant-derived signal molecule, is capable of launching global transcriptional reprogramming to assist plants in obtaining the systemic acquired resistance (SAR) mechanism. Thus, the accurate detection of SA will not only si

A PERSONAL CARE COMPOSITION

-

Page/Page column 16; 17, (2018/09/18)

Disclosed is a personal care composition and a method of providing antiperspirant and anti-inflammation using certain curcuminoid derivatives. The composition comprises: (i) a compound of the Formula 1 Ar-CHnCHn-X.C(R)2-X.CHnCHn-Ar (Formula 1) wherein Ar is a substituted or unsubstituted phenyl group; R is H or CH3; X is CH(OH) group or C=O group; n has the value 1 or 2; and, (ii) a topically acceptable base comprising at least 0.1% of a fragrance wherein, when n=1, the compound of (Formula 1) is 1E,6E)-1,7-bis(3,4- dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione (Formula 2), and when n=2, the compound of (Formula 1) is 1,7-bis(4-hydroxy-3- methoxyphenyl) heptane-3,5-diol (Formula 4) or is 1,7-bis (3,4-dimethoxyphenyl)-4,4-dimethylheptane-3,5-diol (Formula 5).

Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1

Konno, Hiroyuki,Endo, Hitoshi,Ise, Satomi,Miyazaki, Keiki,Aoki, Hideo,Sanjoh, Akira,Kobayashi, Kazuya,Hattori, Yasunao,Akaji, Kenichi

supporting information, p. 685 - 690 (2014/01/23)

To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity. The structure-activity relationship study of curcumin derivatives is described. Our results indicate that phenolic hydroxy groups and an alkenyl spacer are important structural factors for the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 and, furthermore, non-competitive inhibition of enzyme activity is anticipated from an inhibitory kinetics experiment and docking simulation.

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