Chemical Property of Dimethoxycurcumin
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:587.007°C at 760 mmHg
- Flash Point:254.399°C
- PSA：71.06000
- Density:1.169g/cm3
- LogP:3.97590
- XLogP3:3.9
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:10
- Exact Mass:396.15728848
- Heavy Atom Count:29
- Complexity:534
- Purity/Quality:
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99%, *data from raw suppliers
DimethoxyCurcumin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)OC)OC)OC
- Isomeric SMILES:COC1=C(C=C(C=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)OC)OC)OC
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Description
Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities. It inhibits mitogen-induced proliferation of CD4+ T cells, CD8+ T cells, and B cells, as well as secretion of IL-2, IL-4, IL-6, and IFN-γ induced by concanavalin A in isolated human lymphocytes when used at concentrations ranging from 1 to 10 μM. Dimethoxycurcumin (1-10 μM) inhibits LPS-induced nitric oxide (NO) production and expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. It inhibits hemolysis of isolated human red blood cells (RBCs) induced by AAPH when used at a concentration of 10 μM.
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Uses
dimethoxy Curcumin is an analog of curcumin more effective at suppressing HCT116 tumor cells than the parent compound.
