161527-66-8Relevant articles and documents
Selenium-catalyzed carbonylation of 2-aminothiazole with nitro aromatics to N-aryl-N′-2-thiazolylureas
Zhang, Xiaopeng,Tang, Zhaojing,Niu, Xueli,Li, Zhengwei,Fan, Xuesen,Zhang, Guisheng
supporting information, p. 5266 - 5270 (2016/11/11)
An efficient, economical, and phosgene-free procedure for the synthesis of N-aryl-N′-2-thiazolylureas is reported. With cheap and recyclable nonmetal selenium instead of noble metals as the catalyst, carbon monoxide instead of virulent phosgene as the carbonylation agent, the selenium-catalyzed carbonylation reaction of 2-aminothiazole can proceed smoothly in one-pot manner with a variety of nitro aromatics in the presence of triethylamine to afford the desired N-aryl-N′-2-thiazolylureas mostly in moderate to good yields. Selenium catalyst can be easily recovered due to its phase-transfer catalytic ability and reused without any significant degradation of its catalytic performance.
Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-parkinsonian agents
Azam, Faizul,Prasad, Medapati Vijaya Vara,Thangavel, Neelaveni,Shrivastava, Anil Kumar,Mohan, Govind
, p. 1057 - 1068 (2013/01/15)
Synthesis of 1-(substituted aryl)-3-(thiazol-2-yl)urea derivatives was undertaken as our efforts to discover novel antiparkinsonian agents with improved pharmacological profile in haloperidol-induced catalepsy and oxidative stress in mice. Furfuryl, 2- an
