161529-14-2Relevant articles and documents
PEPTIDE-OLIGOUREA HYBRID COMPOUNDS
-
Paragraph 00287-00289, (2020/07/31)
The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
Process for preparing sulfonamide compounds
-
Paragraph 0415; 0453-0456; 0494; 0579-0582, (2020/07/24)
The invention relates to a process for preparing sulfonamide compounds. The sulfonamide compound is an inhibitor of Bcl-2/Bcl-xL and is prepared from a compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorphenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrole-3-yl
iSPAAC: Isomer-Free Generation of a Bcl-xL-Inhibitor in Living Cells
Lis, Christian,Rubner, Stefan,Gr?st, Corinna,Hoffmann, Ralf,Knappe, Daniel,Berg, Thorsten
supporting information, p. 13762 - 13766 (2018/09/14)
Strain-promoted azide–alkyne cycloadditions (SPAAC) have proven extremely useful for labeling of biomolecules, but typically produce isomeric mixtures. This is not appropriate for the formation of bioactive molecules in living cells. Here, the first use o