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1658-97-5

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1658-97-5 Usage

Description

4-Acetyl-N,N-diethyl-benzenesulfonamide, a chemical compound with the molecular formula C14H19NO3S, is a sulfonamide derivative characterized by the presence of an acetyl group and diethyl substituents attached to the benzene ring. 4-ACETYL-N,N-DIETHYL-BENZENESULFONAMIDE is known for its specific chemical properties, which make it a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as a reagent in organic chemistry reactions.

Uses

Used in Pharmaceutical Industry:
4-Acetyl-N,N-diethyl-benzenesulfonamide is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Acetyl-N,N-diethyl-benzenesulfonamide serves as an intermediate in the production of agrochemicals. Its role in this sector is crucial for the development of effective pesticides and other agricultural chemicals that protect crops and enhance agricultural productivity.
Used as a Reagent in Organic Chemistry:
4-Acetyl-N,N-diethyl-benzenesulfonamide is utilized as a reagent in organic chemistry reactions. Its specific chemical properties make it a valuable tool for researchers and chemists in conducting various chemical processes and experiments, further expanding the understanding of organic chemistry and its applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1658-97-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,5 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1658-97:
(6*1)+(5*6)+(4*5)+(3*8)+(2*9)+(1*7)=105
105 % 10 = 5
So 1658-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO3S/c1-4-13(5-2)17(15,16)12-8-6-11(7-9-12)10(3)14/h6-9H,4-5H2,1-3H3

1658-97-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-acetyl-N,N-diethylbenzenesulfonamide

1.2 Other means of identification

Product number -
Other names 4-Acetyl-N,N-diethyl-benzolsulfonamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1658-97-5 SDS

1658-97-5Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors

Yang, Suhui,Shergalis, Andrea,Lu, Dan,Kyani, Anahita,Liu, Ziwei,Ljungman, Mats,Neamati, Nouri

, p. 3447 - 3474 (2019/04/16)

Protein disulfide isomerase (PDI) is responsible for nascent protein folding in the endoplasmic reticulum (ER) and is critical for glioblastoma survival. To improve the potency of lead PDI inhibitor BAP2 ((E)-3-(3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)benzonitrile), we designed and synthesized 67 analogues. We determined that PDI inhibition relied on the A ring hydroxyl group of the chalcone scaffold and cLogP increase in the sulfonamide chain improved potency. Docking studies revealed that BAP2 and analogues bind to His256 in the b′ domain of PDI, and mutation of His256 to Ala abolishes BAP2 analogue activity. BAP2 and optimized analogue 59 have modest thiol reactivity; however, we propose that PDI inhibition by BAP2 analogues depends on the b′ domain. Importantly, analogues inhibit glioblastoma cell growth, induce ER stress, increase expression of G2M checkpoint proteins, and reduce expression of DNA repair proteins. Cumulatively, our results support inhibition of PDI as a novel strategy to treat glioblastoma.

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