170569-86-5 Usage
Description
4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, also known as SC-236, is a highly selective and potent cyclooxygenase-2 (COX-2) inhibitor. It is a white solid that has been shown to induce apoptosis in gastric cells via down-regulation of Akt and subsequent release of cytochrome c. Its anti-inflammatory effects make it a promising candidate for therapy in inflammatory allergic diseases.
Uses
Used in Pharmaceutical Industry:
4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is used as a COX-2 inhibitor for its potential therapeutic applications in treating inflammatory allergic diseases. Its ability to induce apoptosis in gastric cells and down-regulate Akt pathways makes it a valuable compound for further research and development in this field.
Used in Research Applications:
In the research industry, 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, or SC-236, is used as a COX-2 inhibitor to study its effects on various physiological processes, such as the mechano-reflex in rats. This helps researchers to better understand the underlying mechanisms of action and potential applications of this compound in different conditions and diseases.
Biological Activity
Selective COX-2 inhibitor (IC 50 values are 0.005 and 17.8 μ M for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.
Biochem/physiol Actions
SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth. It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 170569-86-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,5,6 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 170569-86:
(8*1)+(7*7)+(6*0)+(5*5)+(4*6)+(3*9)+(2*8)+(1*6)=155
155 % 10 = 5
So 170569-86-5 is a valid CAS Registry Number.
170569-86-5Relevant articles and documents
A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF
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Page/Page column 16-17; 19-20, (2020/08/22)
The present invention relates to preparation of pyrazoles. This invention further relates to a continuous flow micro-total process system for preparation of celecoxib, a COX-2 selective non-steroidal anti-inflammatory drug, and analogs thereof.
Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles
Singh, Sunil K.,Saibaba,Koteswar Rao
, p. 1115 - 1118 (2007/10/03)
The cyclodehydration reaction leading to 1,5-diarylpyrazoles in water medium has been observed for the first time. The method has been used in generating library of compounds for drug discovery program under microwave condition and tried for a multigram synthesis of celecoxib, a premier COX-2 inhibitor, under normal laboratory condition.
COMBINATION OF A SELECTIVE NMDA NR2B ANTAGONIST AND A COX-2 INHIBITOR
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, (2008/06/13)
The present invention provides a combination of a selective NMDA NR2B antagonist and a COX-2 inhibitor for the treatment or prevention of pain or nociception.
