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17794-42-2

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17794-42-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 17794-42-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,9 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17794-42:
(7*1)+(6*7)+(5*7)+(4*9)+(3*4)+(2*4)+(1*2)=142
142 % 10 = 2
So 17794-42-2 is a valid CAS Registry Number.

17794-42-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,4-dinitrophenyl)piperidine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17794-42-2 SDS

17794-42-2Relevant articles and documents

Synthesis of substituted N-(2′-nitrophenyl)pyrrolidine-2-carboxamides towards the design of proline-rich antimicrobial peptide mimics to eliminate bacterial resistance to antibiotics

Odusami, Jocelyn A.,Ikhile, Monisola I.,Izunobi, Josephat U.,Olasupo, Idris A.,Osunsanmi, Foluso O.,Opoku, Andrew R.,Fotsing, Marthe C.D.,Asekun, Olayinka T.,Familoni, Oluwole B.,Ndinteh, Derek T.

, (2020/10/23)

The treatment of diseases is under threat due to the increasing resistance of disease-causing bacteria to antibiotics. Likewise, free radical-induced oxidative stress has been implicated in several human disease conditions, such as cancer, stroke and diabetes. In the search for amino acid analogues with antibacterial and antioxidant properties as possible mimics of antimicrobial peptides, substituted N-(2′-nitrophenyl)pyrrolidine-2-carboxamides 4a–4k and N-(2′-nitrophenyl)piperidine-2-carboxamides 4l–4n have been synthesized via a two-step, one-pot amidation of the corresponding acids, using thionyl chloride with different amines in dichloromethane. The carboxamides were characterized by infrared and nuclear magnetic resonance spectroscopy, mass spectrometry and elemental analysis. Carboxamides 4a–4n were assayed against five Gram-positive and five Gram-negative bacterial strains using the broth micro-dilution procedure and compared to standard antibiotic drugs (streptomycin and nalidixic acid). 4b showed the highest antibacterial activity with a minimum inhibitory concentration (MIC) value of 15.6 μg/mL against Staphylococcus aureus. Pertinently, 4b and 4k are promising candidates for narrow-spectrum (Gram-positive) and broad-spectrum antibiotics, respectively. The antioxidant properties of the carboxamides were also evaluated using the 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical cation. 4a and 4k recorded the lowest IC50 values of 1.22 × 10–3 mg/mL (with DPPH) and 1.45 × 10–4 mg/mL (with ABTS), respectively. Notably, 4k recorded about 2.5 times better antioxidant capacity than the positive controls – ascorbic acid and butylated hydroxyanisole. These results bode well for N-aryl carboxamides as good mimics and substitutes for antimicrobial peptides towards mitigating bacterial resistance to antibiotics as well as ameliorating oxidative stress-related diseases.

Use of the Nuclear Overhauser Effect in the Determination of the Orientation of Aromatic Substitution in Tricyclic Quinoxalinones

Alo, Babajide I.,Avent, Anthony G.,Hanson, James R.,Ode, Alexandra E.

, p. 1997 - 2000 (2007/10/02)

1H N.m.r. nuclear Overhauser enhancement studies involving the amide NH of 7,8,9,10-tetrahydropyridoquinoxalin-6-ones have been used to identify the aromatic proton signals of the quinoxalin-6-ones and to show that bromination with bromine in glaci

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