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4043-87-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4043-87-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,4 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4043-87:
(6*4)+(5*0)+(4*4)+(3*3)+(2*8)+(1*7)=72
72 % 10 = 2
So 4043-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)

4043-87-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name DL-Pipecolinic Acid

1.2 Other means of identification

Product number -
Other names DL-Pipecolinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4043-87-2 SDS

4043-87-2Synthetic route

2-Picolinic acid
98-98-6

2-Picolinic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 20h; Product distribution; Further Variations:; Reagents; Solvents; ratio;100%
With hydrogen; platinum(IV) oxide In ethanol at 125℃; under 18751.5 Torr; for 1h; Irradiation; microwave irradiation;99%
With hydrogen; platinum(IV) oxide In ethanol at 80℃; under 5171.62 Torr; for 0.166667h; microwave irradiation;99%
2-picolinic acid hydrochloride
636-80-6

2-picolinic acid hydrochloride

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In water at 60℃; under 3102.9 Torr; for 5h;100%
With water; platinum Hydrogenation;
1-hydroxypiperidine-2-carboxylic acid
115819-92-6

1-hydroxypiperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal89%
(+/-)-(4-toluenesulfonyl)-piperidine-2-carboxylic acid
56099-73-1, 144630-15-9

(+/-)-(4-toluenesulfonyl)-piperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With naphthalene; sodium In tetrahydrofuran at -78℃; for 0.75h;89%
N-acetylpiperidine-2-carbonitrile
60644-15-7

N-acetylpiperidine-2-carbonitrile

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
acid hydrolysis;55%
L-Lysine hydrochloride
657-27-2, 10098-89-2

L-Lysine hydrochloride

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity;43%
With hydrogen; nickel In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity;33%
With hydrogen; 5% active carbon-supported ruthenium In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity;18%
With hydrogen; platinum on carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity;0%
piperidine
110-89-4

piperidine

formic acid
64-18-6

formic acid

A

isonipecotic acid
498-94-2

isonipecotic acid

B

glycine
56-40-6

glycine

C

pipecolic Acid
4043-87-2

pipecolic Acid

D

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);A 4.3%
B 0.1%
C 0.8%
D 2.9%
1-nitroso-piperidine-2-carboxylic acid
4515-18-8

1-nitroso-piperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies;
2-nitropropane
79-46-9

2-nitropropane

14-(1-ammonio-1-carboxypentyl)-5,6,8,9-tetrahydro-7-(4-methoxy-3-sulphonatophenyl)dibenzoacridinium perchlorate

14-(1-ammonio-1-carboxypentyl)-5,6,8,9-tetrahydro-7-(4-methoxy-3-sulphonatophenyl)dibenzoacridinium perchlorate

A

2-Methoxy-5-(5,6,8,9-tetrahydro-dibenzo[c,h]acridin-7-yl)-benzenesulfonic acid; compound with perchloric acid
92445-40-4

2-Methoxy-5-(5,6,8,9-tetrahydro-dibenzo[c,h]acridin-7-yl)-benzenesulfonic acid; compound with perchloric acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Multistep reaction;
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Yields of byproduct given;
(+/-)-2,6-dibromohexanoic acid
13137-43-4

(+/-)-2,6-dibromohexanoic acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With copper(I) chloride; ammonium hydroxide; ammonium carbonate at 125℃; for 24h; Title compound not separated from byproducts;A 8 % Chromat.
B 44 % Chromat.
2,6-Dichlorhexansaeure
5077-75-8

2,6-Dichlorhexansaeure

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium iodide; hexamethylenetetramine; ammonia In water at 70 - 80℃; for 3h;
2-carboxy-4-methoxypyridin-1-ium chloride
123811-74-5

2-carboxy-4-methoxypyridin-1-ium chloride

(2R,4S)-4-Methoxy-piperidine-2-carboxylic acid
135607-86-2

(2R,4S)-4-Methoxy-piperidine-2-carboxylic acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In ethanol; water at 60℃; under 3102.9 Torr; for 24h; Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; platinum(IV) oxide In ethanol; water at 60℃; under 3102.9 Torr; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
6-Amino-2-chlor-hexansaeure-hydrochlorid
43084-29-3

6-Amino-2-chlor-hexansaeure-hydrochlorid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide at 100℃; for 12h;93 % Chromat.
6-Amino-2-bromhexansaeure-hydrobromid
77300-37-9

6-Amino-2-bromhexansaeure-hydrobromid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature; further reagent: 1N NaOH;34 % Chromat.
(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone
53123-88-9

(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone

A

5-Hydroxy-6-[(1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-2,4-dimethyl-cyclohex-2-enone

5-Hydroxy-6-[(1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-2,4-dimethyl-cyclohex-2-enone

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With sodium hydroxide In methanol for 1h; Heating;A n/a
B 55 mg
With sodium hydroxide In methanol; water Heating;
methyl 1-(trifluoroacetyl)-2-piperidinecarboxylate
129592-96-7

methyl 1-(trifluoroacetyl)-2-piperidinecarboxylate

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With potassium hydroxide In methanol for 2h; Ambient temperature;
2-Amino-6-chlor-hexansaeure-hydrochlorid
70288-85-6

2-Amino-6-chlor-hexansaeure-hydrochlorid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature;58 % Chromat.
2-Amino-6-bromhexansaeure-hydrobromid
10308-06-2

2-Amino-6-bromhexansaeure-hydrobromid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature; further reagent: 1N NaOH;47 % Chromat.
Conditions
ConditionsYield
cadmium(II) sulphide In water at 24.9℃; Rate constant; Product distribution; Mechanism; Irradiation; various time, catalysts, also in D2O; further amino acids;
Piperidine-2-carboxylic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Piperidine-2-carboxylic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With sodium hydroxide In water for 3h; Heating;
L-lysine
56-87-1

L-lysine

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With cadmium(II) sulphide; sodium sulfate In water for 1h; Mechanism; Irradiation; pH 10.1; on titanium(IV) also; stereochemistry of product; tested by FT-IR;
With dihydrogen hexachloroplatinate; titanium(IV) oxide In water at 24.85℃; Kinetics; Further Variations:; Reagents; Irradiation;
With 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one; water; phenol; lysine oxidase; horseradish peroxidase pH=7.5; Conversion of starting material; potassium phosphate/potassium diphosphate buffer;
Pyridine-2,3-dicarboxylic acid
89-00-9

Pyridine-2,3-dicarboxylic acid

cis-2,3-piperidinedicarboxylic acid
82949-15-3

cis-2,3-piperidinedicarboxylic acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol Yield given. Yields of byproduct given;
With hydrogen; palladium on activated charcoal In hydrogenchloride Yield given. Yields of byproduct given;
L-lysine
56-87-1

L-lysine

A

piperidine
110-89-4

piperidine

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
Pt on TiO2 In water Rate constant; Irradiation; different Pt loading of catalyst;
Piperidine-2-carboxylic acid 4-nitro-phenyl ester; hydrobromide

Piperidine-2-carboxylic acid 4-nitro-phenyl ester; hydrobromide

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With Cu complex of polymer from 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane; water In dimethyl sulfoxide at 25℃; Rate constant; var.reag.: Cu(2+) complex of 2,6-bis-benzylaminomethylpyridine; oligomers of 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane;
pyridine-4-carboxylic acid
55-22-1

pyridine-4-carboxylic acid

sulfuric acid
7664-93-9

sulfuric acid

lead-cathodes

lead-cathodes

A

picoline
108-89-4

picoline

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
at 20℃; Electrolysis;
(+-)-6-amino-2-bromo-hexanoic acid

(+-)-6-amino-2-bromo-hexanoic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogenchloride Einengen unter vermindertem Druck;
hydrobromide of/the/ 6-amino-hexanoic acid

hydrobromide of/the/ 6-amino-hexanoic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With phosphorus; bromine anschliessendes Erwaermen und Behandeln der Reaktionsloesung mit wss. Ba(OH)2;
4.5-dichloro-picolinic acid

4.5-dichloro-picolinic acid

A

2-methyl-5-chloropyridine
72093-07-3

2-methyl-5-chloropyridine

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With phosphorous; hydrogen iodide at 160℃;
5-chloro-picolinic acid

5-chloro-picolinic acid

A

2-methyl-5-chloropyridine
72093-07-3

2-methyl-5-chloropyridine

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With phosphorous; hydrogen iodide at 160℃;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

pipecolic Acid
4043-87-2

pipecolic Acid

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid
98303-20-9

1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

Conditions
ConditionsYield
With tetramethyl ammoniumhydroxide In acetonitrile for 72h; Ambient temperature;100%
Stage #1: di-tert-butyl dicarbonate; pipecolic Acid With potassium carbonate In water; acetone at 20℃;
Stage #2: With hydrogenchloride In water; acetone pH=~ 3;
99%
With sodium carbonate In ethanol; water at 20℃;99.6%
methanol
67-56-1

methanol

pipecolic Acid
4043-87-2

pipecolic Acid

methyl piperidine-2-carboxylate hydrochloride
32559-18-5

methyl piperidine-2-carboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃; stereoselective reaction;99%
Stage #1: methanol With thionyl chloride at -30℃;
Stage #2: pipecolic Acid at 0 - 20℃; for 15h;
98%
With thionyl chloride97%
ethanol
64-17-5

ethanol

pipecolic Acid
4043-87-2

pipecolic Acid

ethyl piperidine-2-carboxylate hydrochloride
77034-33-4

ethyl piperidine-2-carboxylate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 24h; Ambient temperature;99%
With thionyl chloride for 2h; Heating;99%
With thionyl chloride for 2h; Reflux;93%
With thionyl chloride 1.) 60 deg C, 2.) RT, 6 h; Yield given. Multistep reaction;
With thionyl chloride at 0 - 90℃; for 4h; Inert atmosphere;
chloroacetonitrile
107-14-2

chloroacetonitrile

pipecolic Acid
4043-87-2

pipecolic Acid

cyanomethyl N-(cyanomethyl)piperidine-2-carboxylate
267220-57-5

cyanomethyl N-(cyanomethyl)piperidine-2-carboxylate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 80℃; for 22h; Alkylation;99%
isatoic anhydride
118-48-9

isatoic anhydride

pipecolic Acid
4043-87-2

pipecolic Acid

7,8,9,10-tetrahydrobenzo[e]pyrido[1,2-a][1,4]diazepine-6,12-(5H,6aH)-dione
41994-17-6

7,8,9,10-tetrahydrobenzo[e]pyrido[1,2-a][1,4]diazepine-6,12-(5H,6aH)-dione

Conditions
ConditionsYield
In dimethyl sulfoxide for 2h; Heating;98%
With 1-n-butyl-3-methylimidazolim bromide at 70℃; for 1.58333h;88%
In N,N-dimethyl-formamide for 2h; Heating;
formic acid
64-18-6

formic acid

pipecolic Acid
4043-87-2

pipecolic Acid

rac-1-formylpiperidine-2-carboxylic acid
54966-20-0

rac-1-formylpiperidine-2-carboxylic acid

Conditions
ConditionsYield
With acetic anhydride at 0 - 20℃;98%
With acetic anhydride at 0 - 20℃;98%
With acetic anhydride at 0 - 20℃;98%
(E)-3-methyl-6-(4-methylbenzylidene)-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one

(E)-3-methyl-6-(4-methylbenzylidene)-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one

pipecolic Acid
4043-87-2

pipecolic Acid

acenaphthene quinone
82-86-0

acenaphthene quinone

3''-methyl-1''-phenyl-1'-(p-tolyl)-1',5',6',7',7'',8',8a',8''-octahydro-2H-dispiro[acenaphthylene-1,3'-indolizine-2',6''-pyrazolo[3,4-b]quinoline]-2,5''(1''H)-dione

3''-methyl-1''-phenyl-1'-(p-tolyl)-1',5',6',7',7'',8',8a',8''-octahydro-2H-dispiro[acenaphthylene-1,3'-indolizine-2',6''-pyrazolo[3,4-b]quinoline]-2,5''(1''H)-dione

Conditions
ConditionsYield
In ethanol Reflux; regioselective reaction;98%
(E)-6-(4-chlorobenzylidene)-3-methyl-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one

(E)-6-(4-chlorobenzylidene)-3-methyl-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one

pipecolic Acid
4043-87-2

pipecolic Acid

acenaphthene quinone
82-86-0

acenaphthene quinone

1'-(4-chlorophenyl)-3''-methyl-1''-phenyl-1',5',6',7',7'',8',8a',8''-octahydro-2H-dispiro[acenaphthylene-1,3'-indolizine-2',6''-pyrazolo[3,4-b]quinoline]-2,5''(1''H)-dione

1'-(4-chlorophenyl)-3''-methyl-1''-phenyl-1',5',6',7',7'',8',8a',8''-octahydro-2H-dispiro[acenaphthylene-1,3'-indolizine-2',6''-pyrazolo[3,4-b]quinoline]-2,5''(1''H)-dione

Conditions
ConditionsYield
In ethanol Reflux; regioselective reaction;98%
methanol
67-56-1

methanol

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 48h;97%
With hydrogenchloride60%
With thionyl chloride at 20℃; for 16h;48%
2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride
837-95-6

2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride

pipecolic Acid
4043-87-2

pipecolic Acid

N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid
130178-58-4

N-(2-nitro-4-trifluoromethylphenylsulphonyl)piperidine-2-carboxylic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; ethanol for 1h; Heating;97%
methyl chloroformate
79-22-1

methyl chloroformate

pipecolic Acid
4043-87-2

pipecolic Acid

(+/-)-[(N-methoxycarbonyl)piperidine]-2-carboxylic acid
134902-40-2

(+/-)-[(N-methoxycarbonyl)piperidine]-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 14h; pH=8 - 9; Inert atmosphere;97%
With sodium hydroxide In water at 20℃; pH=8 - 9; Acylation;
pipecolic Acid
4043-87-2

pipecolic Acid

4-nitrobenzyl chloroformate
4457-32-3

4-nitrobenzyl chloroformate

1-(4-nitrobenzyloxycarbonyl)piperidine-2-carboxylic acid

1-(4-nitrobenzyloxycarbonyl)piperidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃; Shotten-Baumann reaction;97%
2-Picolinic acid
98-98-6

2-Picolinic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With (R)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldiphenylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 20h; Product distribution; Further Variations:; Reagents; Solvents; ratio;100%
With hydrogen; platinum(IV) oxide In ethanol at 125℃; under 18751.5 Torr; for 1h; Irradiation; microwave irradiation;99%
With hydrogen; platinum(IV) oxide In ethanol at 80℃; under 5171.62 Torr; for 0.166667h; microwave irradiation;99%
2-picolinic acid hydrochloride
636-80-6

2-picolinic acid hydrochloride

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In water at 60℃; under 3102.9 Torr; for 5h;100%
With water; platinum Hydrogenation;
1-hydroxypiperidine-2-carboxylic acid
115819-92-6

1-hydroxypiperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal89%
(+/-)-(4-toluenesulfonyl)-piperidine-2-carboxylic acid
56099-73-1, 144630-15-9

(+/-)-(4-toluenesulfonyl)-piperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With naphthalene; sodium In tetrahydrofuran at -78℃; for 0.75h;89%
N-acetylpiperidine-2-carbonitrile
60644-15-7

N-acetylpiperidine-2-carbonitrile

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
acid hydrolysis;55%
L-Lysine hydrochloride
657-27-2, 10098-89-2

L-Lysine hydrochloride

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity;43%
With hydrogen; nickel In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity;33%
With hydrogen; 5% active carbon-supported ruthenium In water at 200℃; under 5171.62 - 51716.2 Torr; for 8h; Product distribution / selectivity;18%
With hydrogen; platinum on carbon In water at 200℃; under 5171.62 Torr; for 8h; Product distribution / selectivity;0%
piperidine
110-89-4

piperidine

formic acid
64-18-6

formic acid

A

isonipecotic acid
498-94-2

isonipecotic acid

B

glycine
56-40-6

glycine

C

pipecolic Acid
4043-87-2

pipecolic Acid

D

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);A 4.3%
B 0.1%
C 0.8%
D 2.9%
1-nitroso-piperidine-2-carboxylic acid
4515-18-8

1-nitroso-piperidine-2-carboxylic acid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies;
2-nitropropane
79-46-9

2-nitropropane

14-(1-ammonio-1-carboxypentyl)-5,6,8,9-tetrahydro-7-(4-methoxy-3-sulphonatophenyl)dibenzoacridinium perchlorate

14-(1-ammonio-1-carboxypentyl)-5,6,8,9-tetrahydro-7-(4-methoxy-3-sulphonatophenyl)dibenzoacridinium perchlorate

A

2-Methoxy-5-(5,6,8,9-tetrahydro-dibenzo[c,h]acridin-7-yl)-benzenesulfonic acid; compound with perchloric acid
92445-40-4

2-Methoxy-5-(5,6,8,9-tetrahydro-dibenzo[c,h]acridin-7-yl)-benzenesulfonic acid; compound with perchloric acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Multistep reaction;
With sodium hydride 1.) water, 25 deg C, 10 min; 2.) water, 80 deg C, 3 h; further solv., var. temp. and time; Yield given. Yields of byproduct given;
(+/-)-2,6-dibromohexanoic acid
13137-43-4

(+/-)-2,6-dibromohexanoic acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With copper(I) chloride; ammonium hydroxide; ammonium carbonate at 125℃; for 24h; Title compound not separated from byproducts;A 8 % Chromat.
B 44 % Chromat.
2,6-Dichlorhexansaeure
5077-75-8

2,6-Dichlorhexansaeure

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium iodide; hexamethylenetetramine; ammonia In water at 70 - 80℃; for 3h;
2-carboxy-4-methoxypyridin-1-ium chloride
123811-74-5

2-carboxy-4-methoxypyridin-1-ium chloride

(2R,4S)-4-Methoxy-piperidine-2-carboxylic acid
135607-86-2

(2R,4S)-4-Methoxy-piperidine-2-carboxylic acid

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In ethanol; water at 60℃; under 3102.9 Torr; for 24h; Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; platinum(IV) oxide In ethanol; water at 60℃; under 3102.9 Torr; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
6-Amino-2-chlor-hexansaeure-hydrochlorid
43084-29-3

6-Amino-2-chlor-hexansaeure-hydrochlorid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide at 100℃; for 12h;93 % Chromat.
6-Amino-2-bromhexansaeure-hydrobromid
77300-37-9

6-Amino-2-bromhexansaeure-hydrobromid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature; further reagent: 1N NaOH;34 % Chromat.
(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone
53123-88-9

(22E,24E,26E,27E,29R,30S,31R,32R,34S,36S,38S,39S,40S,41R,50R)-40,50-dihydroxy-39-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl]-1-methyl-ethyl]-38,41-dimethoxy-29,30,31,32,42,43-hexamethyl-60,61-dioxa-51-azatricyclohexatriaconta-22,24,26(42),27(43)-tetraene-44,45,46,47,48-pentone

A

5-Hydroxy-6-[(1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-2,4-dimethyl-cyclohex-2-enone

5-Hydroxy-6-[(1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-2-methyl-propyl]-2,4-dimethyl-cyclohex-2-enone

B

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With sodium hydroxide In methanol for 1h; Heating;A n/a
B 55 mg
With sodium hydroxide In methanol; water Heating;
methyl 1-(trifluoroacetyl)-2-piperidinecarboxylate
129592-96-7

methyl 1-(trifluoroacetyl)-2-piperidinecarboxylate

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With potassium hydroxide In methanol for 2h; Ambient temperature;
2-Amino-6-chlor-hexansaeure-hydrochlorid
70288-85-6

2-Amino-6-chlor-hexansaeure-hydrochlorid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature;58 % Chromat.
2-Amino-6-bromhexansaeure-hydrobromid
10308-06-2

2-Amino-6-bromhexansaeure-hydrobromid

pipecolic Acid
4043-87-2

pipecolic Acid

Conditions
ConditionsYield
With ammonium hydroxide for 74h; Ambient temperature; further reagent: 1N NaOH;47 % Chromat.
Conditions
ConditionsYield
cadmium(II) sulphide In water at 24.9℃; Rate constant; Product distribution; Mechanism; Irradiation; various time, catalysts, also in D2O; further amino acids;

4043-87-2Relevant articles and documents

-

Gilbertson

, p. 1737 (1972)

-

-

Yagi et al.

, p. 814 (1968)

-

An in situ FT-IR study on photocatalytic reaction at semiconductor-aqueous solution interface - Mechanism of photocatalytic N-cyclization of (S)-lysine

Ohtani, Bunsho,Yako, Takayuki,Samukawa, Yoriaki,Nishimoto, Sei-Ichi,Kanamura, Kiyoshi

, p. 91 - 92 (1997)

Photoinduced reaction occurring at an aqueous solution-semiconductor interface was analyzed in situ by reflection FT-IR spectroscopy. The photoinduced reflection spectral change, ΔR (= (R-R0)/R0), was recorded by using an IR cell consisting of a semiconductor (TiCO2 or CdS) thin film electrode, a thin layer of aqueous (S)-lysine solution, and a calcium fluoride window. Structure of adsorbed substrate and mechanism of photoinduced reaction were discussed.

-

Israeli,Cayouette

, p. 1523,1524-1527 (1971)

-

Recyclable Rh-PVP nanoparticles catalyzed hydrogenation of benzoic acid derivatives and quinolines under solvent-free conditions

Chaudhari, Chandan,Imatome, Hirotaka,Nishida, Yoshihide,Sato, Katsutoshi,Nagaoka, Katsutoshi

, p. 55 - 60 (2019/05/10)

Various transition metal nanoparticles, prepared by microwave-assisted alcohol reduction method were examined for hydrogenation of benzoic acid to cyclohexanecarboxylic acid under solvent-free conditions. Rh metal was the most effective catalyst over other metal catalyst. The catalyst showed moderate to high yield for the hydrogenation of substituted benzoic acid and substituted quinolines. Rh-PVP was recycled four times with a minor loss in catalytic activity.

Focal adhesion kinase inhibitor and use

-

Paragraph 0404; 0406; 0408, (2019/01/08)

The invention belongs to the field of medicines, relates to a focal adhesion kinase inhibitor and use, in particular relates to a novel focal adhesion kinase inhibitor compound, or stereoisomers, geometric isomers, tautomers, oxynitrides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, further relates to the use of the compound and pharmaceutical compositions as medicines, in particular the use of the compound and pharmaceutical compositions in manufacture of medicines for treatment or prevention of cancer, pulmonary hypertension, and pathological angiogenesis-related diseases.

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