178168-21-3 Usage
Uses
(5-Hydroxy-isoxazol-3-yl)-acetic acid is a useful reagent in the preparation of novel peptide epoxyketone derivatives used as inhibitors of proteasomes for treating various conditions or diseases associated with proteasomes
Check Digit Verification of cas no
The CAS Registry Mumber 178168-21-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,1,6 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 178168-21:
(8*1)+(7*7)+(6*8)+(5*1)+(4*6)+(3*8)+(2*2)+(1*1)=163
163 % 10 = 3
So 178168-21-3 is a valid CAS Registry Number.
178168-21-3Relevant articles and documents
PEPTIDE EPOXYKETONE COMPOUNDS
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Paragraph 00189; 00191, (2014/02/16)
The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein are capable of inhibiting all three of CT-L, T-L, and PGPH activities of proteasomes, and are useful in treating various conditions or diseases associated with proteasomes.
