189373-41-9 Usage
Description
DBD-ED, or 4-(2-Aminoethylamino)-7-(N,N-dimethylsulfamoyl)benzofurazan, is a novel precolumn fluorescence derivatization reagent. It is designed to enhance the detection and analysis of various compounds, particularly in the field of biochemistry and pharmaceutical research. The unique chemical structure of DBD-ED allows it to form stable derivatives with a wide range of analytes, improving their detection and quantification in complex samples.
Uses
Used in Biochemical Research:
DBD-ED is used as a fluorescence derivatization reagent for enhancing the detection of various biomolecules in biochemical research. Its application reason is to improve the sensitivity and specificity of analytical techniques, such as high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), by providing a highly fluorescent tag to the target molecules.
Used in Pharmaceutical Analysis:
In the pharmaceutical industry, DBD-ED is used as a derivatization agent for the analysis of drugs and their metabolites. The application reason is to facilitate the identification and quantification of active pharmaceutical ingredients (APIs) and their metabolites in biological samples, such as blood, urine, and tissue homogenates, which is crucial for drug development, quality control, and pharmacokinetic studies.
Used in Environmental Monitoring:
DBD-ED is also used as a precolumn derivatization reagent for the detection and quantification of environmental pollutants and contaminants. The application reason is to improve the sensitivity and accuracy of environmental monitoring methods, allowing for the detection of trace amounts of pollutants in water, soil, and air samples, which is essential for assessing environmental quality and ensuring public health.
Used in Food Analysis:
In the food industry, DBD-ED is used as a fluorescence derivatization reagent for the analysis of additives, contaminants, and other components in the food matrix. The application reason is to enhance the detection and quantification of these components, enabling the assessment of food quality, safety, and compliance with regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 189373-41-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,3,7 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 189373-41:
(8*1)+(7*8)+(6*9)+(5*3)+(4*7)+(3*3)+(2*4)+(1*1)=179
179 % 10 = 9
So 189373-41-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N5O3S/c1-15(2)19(16,17)8-4-3-7(12-6-5-11)9-10(8)14-18-13-9/h3-4,12H,5-6,11H2,1-2H3
189373-41-9Relevant articles and documents
Multiplexing sensory molecules map protons near micellar membranes
Uchiyama, Seiichi,Iwai, Kaoru,De Silva, A. Prasanna
, p. 4667 - 4669 (2008)
(Figure Presented) Hi-fi mapping: Multiplexing fluorescent sensors that simultaneously target proton concentration and polarity move to micellar nanospaces, self-regulate their positions, and report their pKa values and wavelengths, which are c
Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction
Liu, Tingting,Jiang, Yan,Liu, Zhenzhen,Li, Jin,Fang, Kun,Zhuang, Chunlin,Du, Lupei,Fang, Hao,Sheng, Chunquan,Li, Minyong
supporting information, p. 1668 - 1672 (2017/08/22)
A series of probes with a turn-on switch for the p53-MDM2 protein-protein interaction were developed. After careful evaluation, these small molecule fluorescent probes exhibited high practical activity and selectivity in vitro and in cellulo. In particular probe 10, which had a Ki value of 0.03 μM, displayed much better binding affinity compared to the positive control Nutlin-3, which had a Ki value of 0.23 μM. These no-wash environment-sensitive turn-on fluorescent probes have been successfully applied to imaging p53-MDM2 interaction in the human lung cancer cell line A549 (wild-type p53) at the micromolar level. Therefore, these fluorescent probes are expected to be used in drug screening and cell staining in p53-MDM2 fields, as well as in pathological and physiological studies of the p53-MDM2 interaction.
