194935-00-7Relevant articles and documents
Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors
Tempkin, Orin,Abel, Stephan,Chen, Chung-Pin,Underwood, Russell,Prasad, Kapa,Chen, Kau-Ming,Repic, Oljan,Blacklock, Thomas J.
, p. 10659 - 10670 (2007/10/03)
A 'one-pot' conversion of aldehyde 6 to hydroxyketoester 10 with high enantioselection, culminating in a practical asymmetric synthesis of (3R,5S) isomer of the antihyperlipoproteinemic agent fluvastatin, 1, is described. All four 3,5-dihydroxy-6(E)-heptenoate stereoisomers were prepared in enantiopure form starting from 10, utilizing selective reduction and oxidation methods.