93957-50-7

Basic information

• Product Name: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal
• Synonyms: (2E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-2-propenal;(e)-3-[3'-(4"-fluorophenyl)-1'-(1"-methylethyl)-1h-indol-2"-yl]-2-propnal;E-3-(3'-(4-Fluorophenyl)-1-(1'-Methylethyl)-1H-Indole-2-yl)-Prop-3-enaldehyde;(E)-3-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-Indole-2-yl] Propenal;(E)-3-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-PROPENAL;F2 (E)-3-[3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOLE-2-YL] PROPENAL;(E)-3-[3-(4-Fluorophenyl)-1-(isopropyl)-1h-indol-2-yl]-2-propenal;(E)-3-[3''-(4 -FLUOROPHENYL)-1''-(1-METHYLETHYL)-1H-INDOLE-2YL]PROP-2-ENAL
• CAS NO: 93957-50-7
• Molecular Formula: C₂₀H₁₈FNO
• Molecular Weight: 307.3614232
• EINECS: 425-370-4
• Product Categories: Fluvastatin intermediates;Fluvastatine;Fluvastatin
• Mol File: 93957-50-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 129.0 to 133.0 °C
• Boiling Point: 497.643 °C at 760 mmHg
• Flash Point: 254.766 °C
• Appearance: /
• Density: 1.10
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal(93957-50-7)
• EPA Substance Registry System: (E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal(93957-50-7)

Safety Data

• Hazard Codes: Xi:Irritant;; <
• Statements: R43:May cause sensitization by skin contact.; R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects
• Safety Statements: S2:Keep out of the reach of children.; S22:Do not breathe dust. ; S24:Avoid contact with skin.; S37:Wear su
• RIDADR: UN 3077 9/PG III
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 93957-50-7(Hazardous Substances Data)

Usage

General Description

The chemical compound "(E)-3-[3'-(4"-Fluorophenyl)-1'-(1"-methylethyl)-1H-indol-2"-yl]-2-propnal" is a synthetic organic compound with a complex molecular structure. It contains an indole ring, a propenal group, and a fluorophenyl group. The compound is a derivative of indole, a heterocyclic aromatic organic compound, and is likely to have applications in medicinal chemistry due to its structural resemblance to other bioactive compounds. The presence of the fluorophenyl and propenal groups also suggests potential for use in organic synthesis and materials science. Further research and testing would be necessary to fully understand the properties and potential applications of this compound.

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 615-36-1 2-bromoaniline 
• 156643-24-2 2-isopropylamino-1-bromobenzene 
• 768-52-5 N-Isopropylaniline 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 93957-51-8 1-(4-fluorophenyl)-2-(isopropyl(phenyl)amino)ethanone 
• 14189-82-3 3-(N-Methylanilino)-2-propenal 
• 93957-49-4 3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole 
• 109-92-2 ethyl vinyl ether 
• 93-61-8 N-methyl-N-phenylformamide 
• 34900-01-1 3-(N-methyl-N-phenylamino)acrolein 

Downstream Products

• 108998-83-0 (S)-1,1,2-triphenyl-1,2-ethanediol 
• 194934-95-7 ((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester 
• 375846-25-6 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid-1,1-dimethylethyl ester 
• 1254361-95-9 (R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester 
• 1254361-93-7 (S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoic acid isopropyl ester 
• 129332-29-2 R*,S*-(E)-(+/-)-3,5-dihydroxy-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-6-heptenoic acid tert-butyl ester 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Br?nsted Acids Enable Three Molecular Rearrangements of One 3-Alkylidene-2H-1,2-oxazine Molecule into Distinct Heterocyles

This work describes three different strategies to structurally rearrange one 3-alkylidene-2H-1,2-oxazine molecule into three distinct heterocycles using HOTf, propiolic acid, and silica gel, respectively. The mechanisms of these rearrangement reactions in

Palladium-catalyzed synthesis of 2-alkenyl-3-arylindoles via a dual α-arylation strategy: Formal synthesis of the antilipemic drug fluvastatin

A new approach has been developed for the synthesis of substituted 2-alkenyl-3-arylindoles. The strategy comprises palladium-catalyzed dual α-arylation of TES-enol ethers of enones as the key step. This methodology results in products with very good yields and the regioselectivity is exclusive. We have also successfully used this dual α-arylation methodology in the formal synthesis of the cholesterol-lowering drug fluvastatin.

Process for the synthesis of N-methyl-N-phenylaminoacrolein

A process is disclosed for manufacturing N-methyl-N-phenylaminoacrolein of formula (I) which comprises reacting N-methylformanilide and an alkyl vinyl ether of formula (III) wherein R is a C3-C4 alkyl, said process being characterize