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197841-58-0

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  • 1(2H)-Pyridinecarboxylic acid, 2-(3-butenyl)-3,4-dihydro-4-oxo-5-[tris(1-methylethyl)silyl]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

    Cas No: 197841-58-0

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  • (S)-2-But-3-enyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

    Cas No: 197841-58-0

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197841-58-0 Usage

Pyridinecarboxylic acid

A heterocyclic compound with a pyridine ring and a carboxylic acid functional group.

3-butenyl group

An unsaturated hydrocarbon group with four carbon atoms and one double bond.

3,4-dihydro-4-oxo-5-[tris(1-methylethyl)silyl] group

A modified silyl group with a tris(1-methylethyl) substitution and a 3,4-dihydro-4-oxo-5 structure.

(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

A chiral ester with a cyclohexyl ring, a 1-methyl-1-phenylethyl group, and a specific stereochemistry (1S,2R).

(2S)configuration

A specific stereochemistry indicating the arrangement of atoms in the molecule, with the S configuration at the second carbon atom.
These properties and structural components suggest that the compound has a complex and potentially versatile structure, which may lead to various applications in fields such as pharmaceuticals, materials science, or chemical research.

Check Digit Verification of cas no

The CAS Registry Mumber 197841-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,8,4 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 197841-58:
(8*1)+(7*9)+(6*7)+(5*8)+(4*4)+(3*1)+(2*5)+(1*8)=190
190 % 10 = 0
So 197841-58-0 is a valid CAS Registry Number.

197841-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-But-3-enyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:197841-58-0 SDS

197841-58-0Relevant articles and documents

Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Syntheses of Indolizidine Alkaloids (-)-205A, (-)-207A, and (-)-235B

Comins, Daniel L.,LaMunyon, Donald H.,Chen, Xinghai

, p. 8182 - 8187 (2007/10/03)

Concise asymmetric syntheses of indolizidine alkaloids (-)-205A, (-)-207A, and (-)-235B were accomplished with a high degree of stereocontrol in eleven steps. Addition of 4-(1-butenyl)-magnesium bromide to 1-acylpyridinium salt 5, prepared in situ from 4-methoxy-3-(triisopropylsilyl)-pyridine and the chloroformate of (+)trans-2-(α-cumyl)cyclohexanol, gave a 91% yield of diastereomerically pure dihydropyridone 6. Oxidative cleavage of 6 and subsequent reduction provided alcohol 7 in 81% yield. Removal of the chiral auxilliary and TIPS group (NaOMe; 10% HCl), N-acylation with BnOCOCCl, and treatment with NCS/Ph3P gave chloride 10. Methylation at C-3, copper-mediated conjugate addition of 4-(benzyloxy)butylmagnesium bromide, and vinyl triflate formation provided 13 in a stereoselective fashion. Catalytic reduction of the vinyl triflate moiety, simultaneous cleavage of the benzyl ether and Cbz groups, and cyclization to give amino alcohol 14 was effected via a one-pot reaction. Oxidation of 14 with the Dess-Martin reagent gave a 97% yield of amino aldehyde 4. Synthesis of each of the three title alkaloids was accomplished in one step from 4. The Seyferth-Gilbert reaction provided a 41% yield of (-)-205A. The appropriate Wittig olefination of 4 gave indolizidines (-)-207A and (-)-235B in 70% and 86% yield, respectively.

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