197853-44-4Relevant articles and documents
Total synthesis of tricolorin A
Lu, Shou-Fu,O'Yang, QinQin,Guo, Zhong-Wu,Yu, Biao,Hui, Yong-Zheng
, p. 8400 - 8405 (1997)
Tricolorin A (1), a structurally amazing resin glycoside with promising bioactivities from Ipomoea tricolor cav. (convolvulaceae), was synthesized in a total of 45 steps, with the longest linear sequence of 20 steps and overall yield of 0.65% from D-mannitol. The AB disscharide 19-membered lactone 2 was constructured by a regioselective macrolactonization using Corey-Nicolaou protocol. The macrolactone tetrasaccharide 33 was realized either by 'one- pot two-step' glycosylation procedure or by a stepwise assembly employing the 'armed-disarmed' glycosylation strategy.