19934-71-5Relevant articles and documents
An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium-Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution
Perez, Marc,Echeverria, Pierre-Georges,Martinez-Arripe, Elsa,Ez Zoubir, Mehdi,Touati, Ridha,Zhang, Zhaoguo,Genet, Jean-Pierre,Phansavath, Phannarath,Ayad, Tahar,Ratovelomanana-Vidal, Virginie
, p. 5949 - 5958 (2015/09/22)
Thiamphenicol is a widely used antibiotic that exhibits activity against numerous Gram-positive and Gram-negative pathogens. Here, we describe the expedient synthesis of its four stereoisomers through a dynamic kinetic resolution that follows a ruthenium-catalyzed asymmetric hydrogenation or a hydrogen transfer reaction as the key step.