499-67-2

• 

• Basic information

  1. Product Name: proxymetacaine
  2. Synonyms: proxymetacaine;ProxymetacaineHcl;ProxymethacaineHCl;Proxymethacainehydrochloride;Chibro-keracaine;Fluoracaine;2-(Diethylamino)ethyl=3-amino-4-propoxybenzoate;3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester
  3. CAS NO:499-67-2
  4. Molecular Formula: C₁₆H₂₆N₂O₃
  5. Molecular Weight: 294.3892
  6. EINECS: 207-884-9
  7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
  8. Mol File: 499-67-2.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: 182-183.30C
  2. Boiling Point: 434.4 °C at 760 mmHg
  3. Flash Point: 216.5 °C
  4. Appearance: /
  5. Density: 1.065
  6. Vapor Pressure: 9.5E-08mmHg at 25°C
  7. Refractive Index: 1.527
  8. Storage Temp.: Refrigerator
  9. Solubility: N/A
  10. PKA: 9.20±0.25(Predicted)
  11. CAS DataBase Reference: proxymetacaine(CAS DataBase Reference)
  12. NIST Chemistry Reference: proxymetacaine(499-67-2)
  13. EPA Substance Registry System: proxymetacaine(499-67-2)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 499-67-2(Hazardous Substances Data)

• Suppliers
• Usage
• SDS
• Synthetic route
• Upstream product
• Downstream Products
• Article

499-67-2 Suppliers

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• proxymetacaine

  Cas No: 499-67-2

• USD $ 3.0-3.0 / Kilogram

• 1 Kilogram

• 1-100 Metric Ton/Month

• Dayang Chem (Hangzhou) Co.,Ltd.
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• High quality Proxymetacaine Hcl supplier in China

  Cas No: 499-67-2

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• Simagchem Corporation
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• Proparacaine , 499-67-2

  Cas No: 499-67-2

• USD $ 1.0-1.0 / Kilogram

• 1 Kilogram

• 800 Metric Ton/Year

• Henan Sinotech Import&Export Corporation
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• Benzoic acid,3-amino-4-propoxy-, 2-(diethylamino)ethyl ester

  Cas No: 499-67-2

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• 1 Gram

• 10000 Metric Ton/Month

• Shanghai Upbio Tech Co.,Ltd
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• proxymetacaine CAS:499-67-2

  Cas No: 499-67-2

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• 1 Gram

• 3 Metric Ton/Month

• Qingdao Beluga Import and Export Co., LTD
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• Proparacaine

  Cas No: 499-67-2

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• 1 Kilogram

• 1 Metric Ton/Day

• Shandong Hanjiang Chemical Co., Ltd.
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• Benzoic acid,3-amino-4-propoxy-, 2-(diethylamino)ethyl ester

  Cas No: 499-67-2

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• 10000 Metric Ton/Month

• Henan Wentao Chemical Product Co., Ltd.
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• Benzoic acid,3-amino-4-propoxy-, 2-(diethylamino)ethyl ester

  Cas No: 499-67-2

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• 5

• Hangzhou J&H Chemical Co., Ltd.
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• High quality Proxymetacaine Hcl

  Cas No: 499-67-2

• USD $ 100.0-100.0 / Gram

• 10 Gram

• 500 Kilogram/Month

• Zibo Hangyu Biotechnology Development Co., Ltd
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• proxymetacaine

  Cas No: 499-67-2

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• 10 Gram

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• TaiChem Taizhou Limited
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499-67-2 Usage

Chemical Properties

Crystalline Solid

Uses

Topical anesthetic (ophthalmic)

Brand name

Alcaine (Alcon); Ophthetic (Allergan); Paracaine (Optopics).

Check Digit Verification of cas no

The CAS Registry Mumber 499-67-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 499-67:
(5*4)+(4*9)+(3*9)+(2*6)+(1*7)=102
102 % 10 = 2
So 499-67-2 is a valid CAS Registry Number.

InChI:InChI=1/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3

499-67-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	Proparacaine Hydrochloride

1.2 Other means of identification

Product number	-
Other names	2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:499-67-2 SDS

499-67-2Synthetic route

736870-51-2

3-nitro-4-propoxy-benzoic acid-(2-diethylamino-ethyl ester)

499-67-2

Proparacain

Conditions

Conditions	Yield
With ethanol; platinum Hydrogenation;

616-82-0

3-nitro-4-hydroxybenzoic acid

499-67-2

Proparacain

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: K2CO3; xylene / Erwaermen des Reaktionsprodukts mit wss.-aethanol. NaOH 2: isopropyl alcohol 3: platinum; ethanol / Hydrogenation View Scheme

35288-44-9

3-nitro-4-propoxybenzoic acid

499-67-2

Proparacain

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: isopropyl alcohol 2: platinum; ethanol / Hydrogenation View Scheme

499-67-2Upstream product

• 35288-44-9 3-nitro-4-propoxybenzoic acid 
• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 736870-51-2 3-nitro-4-propoxy-benzoic acid-(2-diethylamino-ethyl ester) 

499-67-2Downstream Products

499-67-2Relevant articles and documents

Synthesis of proxymetacaine : [2 diethylaminoethyl] 3 amino 4 n propoxybenzoate (laboratory note)

Monguzzi,Pinza,Pifferi

, p. 214 - 215 (2007/10/06)

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