35288-44-9

Usage

Uses

Used in Organic Synthesis:
4-Propoxy-3-nitrobenzoic acid is used as a key intermediate in organic synthesis for the creation of a variety of chemical compounds. Its unique structure allows for multiple points of reactivity, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-Propoxy-3-nitrobenzoic acid is utilized as a building block for the development of new drugs and biologically active compounds. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final drug product, enhancing its therapeutic potential.
Used in Dye and Pigment Production:
4-Propoxy-3-nitrobenzoic acid is used as a precursor in the production of dyes and pigments, contributing to the coloration and stability of these products. Its chemical properties enable the creation of a wide range of colors and hues, important for various applications in the textile, paint, and printing industries.
Safety Precautions:
Due to its potential harmful effects, 4-Propoxy-3-nitrobenzoic acid should be handled and stored with proper safety measures. It is known to be harmful if ingested or inhaled and may cause skin and eye irritation upon contact. Therefore, appropriate personal protective equipment (PPE) and handling procedures must be followed to minimize any health risks associated with its use.

InChI:InChI=1/C10H11NO5/c1-2-5-16-9-4-3-7(10(12)13)6-8(9)11(14)15/h3-4,6H,2,5H2,1H3,(H,12,13)

Upstream product

• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 599-91-7 propyl tosylate 
• 1221258-88-3 3-nitro-4-propoxybenzoic acid propyl ester 
• 59691-12-2 methyl 3-nitro-4-propoxybenzoate 

Downstream Products

• 736870-51-2 3-nitro-4-propoxy-benzoic acid-(2-diethylamino-ethyl ester) 
• 499-67-2 Proparacain 
• 59691-15-5 3-amino-4-propoxybenzoic acid 

Relevant academic research and scientific papers

N-(3-nitro-4-alkoxybenzoyl)amino acid compounds as well as preparation method and application thereof

The invention discloses N-(3-nitro-4-alkoxybenzoyl)amino acid compounds as well as a preparation method and an application thereof and belongs to the field of medicines. 4-hydroxy-3-nitrobenzoic acidis subjected to methanol esterification, bromo-alkane substitution, hydrolysis and chlorination and then acylated with L-phenylglycine, R2 which is L-phenylglycine sodium salt is obtained, and the N-(3-nitro-4-alkoxybenzoyl)amino acid compounds are obtained after hydrolysis. The N-(3-nitro-4-alkoxybenzoyl)amino acid compounds have novel chemical structures, have good effects in an in-vitro xanthine oxidase inhibition activity test and can be used for treating and preventing gout diseases.

ORGANIC COMPOUNDS

Novel benzofuran derivatives are disclosed. The derivatives have S1P1 receptor activity and/or disease modifying activity and find use in the treatment of conditions or diseases associated with the immune, vascular and nervous systems in animals and/or humans

S1P RECEPTORS MODULATORS AND THEIR USE THEREOF

The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.

S1P RECEPTORS MODULATORS

The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.

PROCESS FOR PRODUCING 3-NITRO-4-ALKOXYBENZOIC ACID

The present invention provides a process for preparing 3-nitro-4-alkoxybenzoic acid, which comprises the step of subjecting a mixture comprising 4-alkoxybenzoic acid and 40-80% nitric acid, wherein the amount of the 40-80% nitric acid is equal to or more than 8 times that of 4-alkoxybenzoic acid by weight, to a reaction at a temperature of 30-100°C.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.