5997-01-3

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• Basic information

  1. Product Name: 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide
  2. Synonyms: 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide
  3. CAS NO:5997-01-3
  4. Molecular Formula: C₄H₁₀N₂S
  5. Molecular Weight: 118.2
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 5997-01-3.mol
  9. Article Data: 6

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: 1.379g/cm³
  6. Refractive Index: 1.654
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide(CAS DataBase Reference)
  10. NIST Chemistry Reference: 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide(5997-01-3)
  11. EPA Substance Registry System: 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide(5997-01-3)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 5997-01-3(Hazardous Substances Data)

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• 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide

  Cas No: 5997-01-3

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5997-01-3 Usage

General Description

2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide is a complex chemical compound with a pyrrolidine-1-carboxamide backbone and additional functional groups including a 1,2,4-oxadiazol-5-yl ring and a 4-methylphenyl substituent. It also contains a 4-nitrophenyl group. 2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide is likely to have significant interactions and effects due to its structural complexity and the presence of these various functional groups. It may hold potential for use in pharmaceutical research and development as a drug candidate, as the combination of these structural features could potentially impart specific biological activity and therapeutic properties. Further study and analysis of this compound are warranted to fully understand its potential applications and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 5997-01-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,9 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5997-01:
(6*5)+(5*9)+(4*9)+(3*7)+(2*0)+(1*1)=133
133 % 10 = 3
So 5997-01-3 is a valid CAS Registry Number.

InChI:InChI=1/C20H19N5O4/c1-13-4-6-14(7-5-13)18-22-19(29-23-18)17-3-2-12-24(17)20(26)21-15-8-10-16(11-9-15)25(27)28/h4-11,17H,2-3,12H2,1H3,(H,21,26)

5997-01-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]-N-(4-nitrophenyl)pyrrolidine-1-carboxamide

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5997-01-3 SDS

5997-01-3Upstream product

• 26541-51-5 N-nitroso thiomorpholine 

5997-01-3Downstream Products

• 31898-55-2 [2-(5-nitro-thiophen-2-yl)-thiazol-4-ylmethylene]-thiomorpholin-4-yl-amine 
• 54738-42-0 {4-[2-(5-nitro-1-vinyl-1H-imidazol-2-yl)-vinyl]-benzylidene}-thiomorpholin-4-yl-amine 
• 75161-22-7 N-Cyclohexylidenamino-thiomorpholin 
• 75161-24-9 N-Benzylidenamino-thiomorpholin 
• 75161-25-0 N-(p-Aminobenzyliden)-amino-thiomorpholin 
• 75161-26-1 N-(p-Nitrobenzyliden)-amino-thiomorpholin 

5997-01-3Relevant articles and documents

Optimization of biaryloxazolidinone as promising antibacterial agents against antibiotic-susceptible and antibiotic-resistant gram-positive bacteria

Wu, Yachuang,Ding, Xiudong,Yang, Yifeng,Li, Yingxiu,Qi, Yinliang,Hu, Feng,Qin, Mingze,Liu, Yajing,Sun, Lu,Zhao, Yanfang

, (2019/10/23)

We previously discovered a series of novel biaryloxazolidinone analogues bearing a hydrazone moiety with potent antibacterial activity. However, the most potent compound OB-104 exhibited undesirable chemical and metabolic instability. Herein, novel biaryloxazolidinone analogues were designed and synthesized to improve the chemical and metabolic stability. Compounds 6a-1, 6a-3, 14a-1, 14a-3 and 14a-7 showed significant antibacterial activity against the tested Gram-positive bacteria as compared to radezolid and linezolid. Further studies indicated that most of them exhibited improved water solubility and chemical stability. Compound 14a-7 had MIC values of 0.125–0.25 μg/mL against all tested Gram-positive bacteria, and showed excellent antibacterial activity against clinical isolates of antibiotic-susceptible and antibiotic-resistant bacteria. Moreover, it was stable in human liver microsome. From a safety viewpoint, it showed non-cytotoxic activity against hepatic cell and exhibited lower inhibitory activity against human MAO-A compared to linezolid. The potent antibacterial activity and all these improved drug-likeness properties and safety profile suggested that compound 14a-7 might be a promising drug candidate for further investigation.

NEW DRUGS WITH ANTICHOLESTATIC ACTIVITY

-

Page/Page column 25, (2009/03/07)

New compounds belonging to the structural formula (I) are described. formula (I) in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.

ALPHA-MERCAPTOMETHYL-BENZENE PROPANAMIDES, PHARMACEUTICAL COMPOSITIONS AND USE

-

, (2008/06/13)

Novel α-mercaptomethyl-benzene propanamides of the formula STR1 wherein R 1 is selected from the group consisting of hydrogen and STR2 R 1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of--OH,--NO 2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms,--OH, halogen and--CF 3, R 2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms,--OH,--NO. sub.2,--CF 3, halogen and acyl of an organic carboxylic acid of 1 to 7 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity, antidepression and anxiolytic properties.

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