799814-32-7Relevant articles and documents
Phosphonium Ylide-Mediated Programmable Fluorination to Access Mono- And Difluoromethylarenes
Zheng, Yu,Xie, Zhen-Zhen,He, Xian-Chen,Chen, Yan-Shan,Cheng, Wen-Shuo,Chen, Kai,Xiang, Hao-Yue,Chen, Xiao-Qing,Yang, Hua
supporting information, p. 2538 - 2542 (2021/04/13)
Compounds bearing fluorinated moieties are pervasive in a wide range of pharmaceuticals and agrochemicals. The installation of fluorinated units is a persistently vital task in synthetic chemistry, where facile and manipulable assays are highly demanding.
Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization
Zhang, Xue,Ling, Liang,Luo, Meiming,Zeng, Xiaoming
supporting information, p. 16785 - 16789 (2019/11/11)
Reported here is a straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates the preferential addition of hydrogen to the substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction. This strategy enables the diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes and saturated heterocycles, and even allows formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicate that hydrogen preferentially attacks the substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as the reactive species, followed by either reversible or irreversible hydrogen addition to the nonsubstitution sites.
PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY
-
Page/Page column 45, (2016/09/26)
The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
