100004-81-7Relevant academic research and scientific papers
THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0180, (2020/12/11)
Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
Synthesis in 3 Azafluorene Group. Part-III
Chatterjea, J. N.,Shaw, S. C.,Prasad, Y.,Singh, R. P.
, p. 1028 - 1031 (2007/10/02)
The Hey-Elks route to arylated pyridines has been utilised in the synthesis of 3-azafluorenes.The pyrido-coumarin (23) and the related chromene (24) have been synthesised.
