5958-01-0

Basic information

• Product Name: 3-(2-METHOXYPHENYL)PYRIDINE
• Synonyms: 3-(2-METHOXYPHENYL)PYRIDINE;AKOS BAR-0418
• CAS NO: 5958-01-0
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 5958-01-0.mol
• Article Data: 34

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-METHOXYPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHOXYPHENYL)PYRIDINE(5958-01-0)
• EPA Substance Registry System: 3-(2-METHOXYPHENYL)PYRIDINE(5958-01-0)

Safety Data

• Hazardous Substances Data: 5958-01-0(Hazardous Substances Data)

Upstream product

• 626-60-8 3-Chloropyridine 
• 100-66-3 methoxybenzene 
• 140-88-5 ethyl acrylate 
• 335643-08-8 2-bromo-3-(2-methoxy-phenyl)-pyridine 
• 110-86-1 pyridine 
• 529-28-2 4-iodoanisol 
• 766-51-8 2-Chloroanisole 
• 329214-79-1 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 626-55-1 3-Bromopyridine 
• 1692-25-7 3-pyridylboronic acid 
• 20240-99-7 1-(2-Methoxyphenyl)-3,3-dimethyltriazen 
• 111042-61-6 (E)-1-(furan-2-yl)-3 (2-methoxyphenyl)-2-propen-1-one 
• 201230-82-2 carbon monoxide 
• 5720-06-9 2-Methoxyphenylboronic acid 

Downstream Products

• 851595-35-2 2-chloro-5-(2-methoxy-phenyl)-pyridine 
• 851595-47-6 2,3-dichloro-5-(2-methoxy-phenyl)-pyridine 
• 19737-63-4 3-(2-methoxyphenyl)-piperidine 
• 54168-07-9 3-(2-hydroxyphenyl)pyridine 

Relevant articles and documents

Decarbonylative Pd-Catalyzed Suzuki Cross-Coupling for the Synthesis of Structurally Diverse Heterobiaryls

Heteroaromatic biaryls are core scaffolds found in a plethora of pharmaceuticals; however, their direct synthesis by the Suzuki cross-coupling is limited to heteroaromatic halide starting materials. Here, we report a direct synthesis of diverse nitrogen-containing heteroaromatic biaryls by Pd-catalyzed decarbonylative Suzuki cross-coupling of widely available heterocyclic carboxylic acids with arylboronic acids. The practical and modular nature of this cross-coupling enabled the straightforward preparation of >45 heterobiaryl products using pyridines, pyrimidines, pyrazines, and quinolines in excellent yields. We anticipate that the modular nature of this protocol will find broad application in medicinal chemistry and drug discovery research.

Carboxyamido/carbene ligated palladium (II) complex: A versatile catalyst for the synthesis of aryl-substituted heteroarenes

Carboxy amido/carbene ligated Pd-complex catalyzed Suzuki-Miyaura cross-coupling of aryl-boronic acids with heteroaryl bromides is described. The protocol has a broad substrate scope that includes electron-rich, electron-deficient and sterically hindered arylboronic acids and heteroaryl bromides. The catalytic activity of the catalyst has been further investigated in the coupling of 2,6-dibromopyridine with arylboronic acids.

PIPERIDINE AND AZEPINE DERIVATIVES AS PROKINETICIN RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R1, R2, R3 and R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.