1000045-67-9

Upstream product

• 1000045-31-7 (3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one 
• 1187941-54-3 C₃₄H₆₀N₄O₈ 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 1000045-69-1 N-[4-methoxy-3-(3-methoxypropoxy)benzyl]propan-2-amine 
• 1000045-29-3 N-{(1S)-2-hydroxy-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide 

Downstream Products

• 1000045-68-0 (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-6-{isopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}hexanamide fumarate 

Relevant academic research and scientific papers

Efficient synthesis of 5-amino-6-dialkylamino-4-hydroxypentanamide derivatives for renin inhibitors

We report an efficient synthetic method for 5-amino-6-dialkylamino-4- hydroxypentanamide derivatives using Shi Asymmetric Epoxidation and the ring opening of N-(2-nitrobenzenesulfonyl)aziridine with hindered secondary amine as key steps. The Japan Institute of Heterocyclic Chemistry.

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P1 motif were designed based on initial lead structures 1 and aliskiren (2). (P3-P1)-Benzamide derivatives such as 9a and 34, as well as the corresponding P1 basic tertiary amine derivatives 10 and 35 were found to display low nanomolar inhibition against human renin in vitro.