1000152-84-0

Usage

Uses

Used in Pharmaceutical Industry:
2,6-DibroMo-4-(trifluoroMethyl)pyridine is used as an intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic effects.
Used in Agricultural Industry:
In the agricultural sector, 2,6-DibroMo-4-(trifluoroMethyl)pyridine serves as an intermediate for the production of crop protection products. Its chemical properties contribute to the creation of effective agents for pest and disease control in agriculture.
Used in Organic Synthesis:
2,6-DibroMo-4-(trifluoroMethyl)pyridine is utilized as a building block in organic synthesis. Its presence in various chemical reactions enables the formation of a wide range of compounds with diverse applications.
Used as a Ligand in Metal-Catalyzed Reactions:
2,6-DibroMo-4-(trifluoroMethyl)pyridine also functions as a ligand in metal-catalyzed reactions, enhancing the efficiency and selectivity of these processes. Its role in catalysis is crucial for the synthesis of complex organic molecules.
Used in Drug Discovery and Development:
2,6-DibroMo-4-(trifluoroMethyl)pyridine has shown promise as a potential inhibitor of enzyme activity. Its ability to modulate enzyme function makes it valuable in drug discovery and development, particularly for the creation of new therapeutic agents targeting specific enzymes.
Overall, 2,6-DibroMo-4-(trifluoroMethyl)pyridine is a significant chemical compound with a broad spectrum of applications across different industries, making it an essential component in the development of new products and research advancements.

Upstream product

• 39890-98-7 2,6-dichloro-4-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

We describe our optimization efforts to improve the physicochemical properties, solubility, and off-target profile of 1, an inhibitor of TarO, an early stage enzyme in the biosynthetic pathway for wall teichoic acid (WTA) synthesis. Compound 1 displayed a TarO IC50 of 125 nM in an enzyme assay and possessed very high lipophilicity (clogP = 7.1) with no measurable solubility in PBS buffer. Structure-activity relationship (SAR) studies resulted in a series of compounds with improved lipophilic ligand efficiency (LLE) consistent with the reduction of clogP. From these efforts, analog 9 was selected for our initial in vivo study, which in combination with subefficacious dose of imipenem (IPM) robustly lowered the bacterial burden in a neutropenic Staphylococci murine infection model. Concurrent with our in vivo optimization effort using 9, we further improved LLE as exemplified by a much more druglike analog 26.

PEST CONTROL AGENT CONTAINING NOVEL PYRIDYL-METHANAMINE DERIVATIVE OR SALT THEREOF

A novel pesticide is provided. The present invention provides a pesticide containing, as an active ingredient, a pyridyl-methanamine derivative represented by the formula (I) or its salt: wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; each of R2 and R3 which are independent of each other, is hydrogen, halogen, cyano, nitro, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; R4 is trifluoromethyl or chlorodifluoromethyl; R5 is hydrogen, halogen, cyano, nitro, alkyl, etc.; each of R6 and R7 which are independent of each other, is hydrogen, cyano, alkyl, haloalkyl, etc.; R8 is alkyl, cycloalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, hydroxyalkyl, halogen, haloalkyl, cyano, nitro, etc.; and n is an integer of from 0 to 4.