1000192-31-3Relevant academic research and scientific papers
Tubulin modulating antifungal and antiproliferative pyrazinone derivatives
Taggi, Andrew E.,Stevenson, Thomas M.,Bereznak, James F.,Sharpe, Paula L.,Gutteridge, Steven,Forman, Robert,Bisaha, John J.,Cordova, Daniel,Crompton, Martina,Geist, Lora,Kovacs, Patrick,Marshall, Eric,Sheth, Ritesh,Stavis, Courtney,Tseng, Chi-Ping
, p. 435 - 443 (2016/01/25)
A novel class of synthetic tubulin polymerization disruptors, based on a substituted pyrazin-2-one core, has been discovered. These molecules have proven to be potent broad spectrum fungicides, with activity on agriculturally important ascomycete and basidiomycete pathogens. They have also been found to be particularly potent against human rhabdomyosarcoma cells. Using an efficient synthetic route, the agricultural and medicinal activity was explored.
FUNGICIDAL PYRAZINE DERIVATIVES
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Page/Page column 100, (2008/06/13)
Compounds of Formula 1, and their N -oxides and agriculturally suitable salts, are disclosed as useful as fungicides (INSERT FORMULA I HERE) wherein R1 isNR4R5, N=CR19R21, OR6, G1 or G2; or C1-C8 alkyl, C2-C8 alkenyl, each optionally substituted; A is O, S or NR7; R2 is cyano, NR8 N=CR9R10, NC(=O)R30; or a 5- or 6-membered heteroaromatic ring, each ring or ring system optionally substituted; R?3? is H, halogen, cyano, C1-C6 alkyl; J is C1-C8 alkyl or phenyl, optionally substituted; and R4, R5, R6, R7, R8, R9, R10, R19, R21, R30, G1 and G2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula 1.
