1000197-89-6Relevant academic research and scientific papers
Tubulin modulating antifungal and antiproliferative pyrazinone derivatives
Taggi, Andrew E.,Stevenson, Thomas M.,Bereznak, James F.,Sharpe, Paula L.,Gutteridge, Steven,Forman, Robert,Bisaha, John J.,Cordova, Daniel,Crompton, Martina,Geist, Lora,Kovacs, Patrick,Marshall, Eric,Sheth, Ritesh,Stavis, Courtney,Tseng, Chi-Ping
, p. 435 - 443 (2016/01/25)
A novel class of synthetic tubulin polymerization disruptors, based on a substituted pyrazin-2-one core, has been discovered. These molecules have proven to be potent broad spectrum fungicides, with activity on agriculturally important ascomycete and basidiomycete pathogens. They have also been found to be particularly potent against human rhabdomyosarcoma cells. Using an efficient synthetic route, the agricultural and medicinal activity was explored.
PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS
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, (2008/06/13)
This invention pertains to a method of inhibiting undesired animal cellular proliferation said method comprising contacting an animal cell with a compound of Formula 1 and all pharmaceutically acceptable, salts, N-oxides, hydrates, solvates, or geometric and stereoisomers thereof: Formula (I) wherein R1 is NR4 R5, N=CR19 R21 OR6, G1 or G2; or C1-C8 alkyl, C2-C8 alkenyl, each optionally substituted; A is O, S or NR7; R2 is cyano, NR8-N=CR9 R10 or NC(=O)R30; or a 5- or 6-membered heteroaromatic ring, each ring or ring system optionally substituted; R3 is H, halogen, cyano, C1-C6 alkyl; J is C1- C8 alkyl or phenyl, optionally substituted; and R4, R5, R6, R7, R8, R9, R10, R19, R21, R30, G1 and G2 are defined in the disclosure.
